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anti-ALAS1 antibody :: Rabbit anti-Human ALAS1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241820
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALAS1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human ALAS1

 Product Synonym Names    Anti-ALAS1 Antibody (aa480-530) IHC-plus; ALAS1; ALAS; ALAS-H; ALAS3; ALASH; Delta-ALA synthase 1; MIG4; Migration-inducing protein 4; Human ALAS1
 Product Gene Name   

anti-ALAS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125290
 3D Structure    ModBase 3D Structure for P13196
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    A portion of amino acids 480-530 of human ALAS-1 was used as the immunogen.
 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.05% BSA, 0.05% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human ALAS1.
 Immunogen Type    Synthetic peptide
 Immunogen    ALAS1 antibody was raised against synthetic peptide from human ALAS1.
 Antigen Modification    aa480-530
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 Preparation and Storage    Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-ALAS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ALAS1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-ALAS1 antibody    IHC-P (5 ug/ml), WB (1 - 3 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-ALAS1 antibody    Anti-ALAS1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ALAS1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ALAS1 antibody    Western blot of ALAS-1 in HepG2 cell lysate using antibody at 1 ug/ml.
anti-ALAS1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ALAS1. It may not necessarily be applicable to this product.
 NCBI GI #    4502025
 NCBI GeneID    211
 NCBI Accession #    NP_000679.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000688.5 [Other Products]
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 UniProt Primary Accession #    P13196 [Other Products]
 UniProt Related Accession #    P13196 [Other Products]
 Molecular Weight    12,961 Da
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 NCBI Official Full Name    5-aminolevulinate synthase, nonspecific, mitochondrial
 NCBI Official Synonym Full Names    5'-aminolevulinate synthase 1
 NCBI Official Symbol    ALAS1 [Similar Products]
 NCBI Official Synonym Symbols   
ALAS; MIG4; ALAS3; ALASH
[Similar Products]
 NCBI Protein Information    5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; delta-ALA synthase 1; migration-inducing protein 4; 5-aminolevulinic acid synthase 1; delta-aminolevulinate synthase 1; aminolevulinate, delta-, synthase 1
 UniProt Protein Name    5-aminolevulinate synthase, nonspecific, mitochondrial
 UniProt Synonym Protein Names   
5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1
 Protein Family    Alanine--tRNA ligase
 UniProt Gene Name    ALAS1 [Similar Products]
 UniProt Synonym Gene Names    ALAS3; ALASH; ALAS-H [Similar Products]
 UniProt Entry Name    HEM1_HUMAN
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 NCBI Summary for ALAS1    This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
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 UniProt Comments for ALAS1    ALAS1: the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Protein type: Transferase; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 2.3.1.37

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm

Molecular Function: 5-aminolevulinate synthase activity; pyridoxal phosphate binding

Biological Process: mitochondrion organization and biogenesis; organelle organization and biogenesis; porphyrin metabolic process; cellular lipid metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process
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 Research Articles on ALAS1    1. The -853T variant functions as an enhancer in the presence of estrogen and speculates that the -1253A variant reduces transcription activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALAS1 antibodyPathways associated with anti-ALAS1 antibody
 Reference Product  PubMed Publications
 ALAD antibody  >2 publications with ALAS1 and ALAD
 Products by Pathway  Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Heme Biosynthesis Pathway antibodies  Heme Biosynthesis Pathway Diagram
 Heme Biosynthesis Pathway antibodies  Heme Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Porphyrins Pathway antibodies  Metabolism Of Porphyrins Pathway Diagram
Diseases associated with anti-ALAS1 antibodyOrgans/Tissues associated with anti-ALAS1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >13 publications with ALAS1 and Liver Diseases
 Porphyrias Antibodies  >11 publications with ALAS1 and Porphyrias
 Inflammation Antibodies  >6 publications with ALAS1 and Inflammation
 Anemia Antibodies  >3 publications with ALAS1 and Anemia
 Carcinoma, Hepatocellular Antibodies  >2 publications with ALAS1 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >2 publications with ALAS1 and Necrosis
 Disease Models, Animal Antibodies  >2 publications with ALAS1 and Disease Models, Animal
 Heart Diseases Antibodies  >2 publications with ALAS1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >2 publications with ALAS1 and Cardiovascular Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with ALAS1 and Drug-Related Side Effects and Adverse Reactions
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >27 publications with ALAS1 and Liver
 Blood Antibodies  >7 publications with ALAS1 and Blood
 Muscle Antibodies  >6 publications with ALAS1 and Muscle
 Brain Antibodies  >4 publications with ALAS1 and Brain
 Lung Antibodies  >3 publications with ALAS1 and Lung
 Ovary Antibodies  >3 publications with ALAS1 and Ovary
 Testis Antibodies  >2 publications with ALAS1 and Testis
 Uterus Antibodies  >2 publications with ALAS1 and Uterus
 Embryonic Tissue Antibodies  >2 publications with ALAS1 and Embryonic Tissue
 Heart Antibodies  >2 publications with ALAS1 and Heart
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