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anti-ALDH18A1 antibody :: Goat ALDH18A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422476
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALDH18A1, Polyclonal Antibody

 Also Known As   

Goat anti-ALDH18A1 Antibody

 Product Synonym Names    ALDH18A1; aldehyde dehydrogenase 18 family, member A1; GSAS; MGC117316; P5CS; PYCS; aldehyde dehydrogenase 18A1; delta1-pyrroline-5-carboxlate synthetase; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase); aldehyde dehydrogenase 18 family; member A1 antibody; aldehyde dehydrogenase 18A1 antibody; delta1-pyrroline-5-carboxlate synthetase antibody; GSAS antibody; MGC117316 antibody; P5CS antibody; PYCS antibody; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase) antibody; ALDH18A1 antibody
 Product Gene Name   

anti-ALDH18A1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ALDH18A1 peptide (MBS427422) is used for blocking the activity of ALDH18A1 antibody (MBS422476)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SEHGSLKYLH
 OMIM    138250
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-SEHGSLKYLH, from the C Terminus of the protein sequence according to NP_002851.2; NP_001017423.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognize both reported isoforms (NP_002851.2; NP_001017423.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ALDH18A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ALDH18A1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ALDH18A1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 85kDa band observed in lysates of cell lines NIH3T3 and MCF7 (calculated MW of 87.3kDa according to NP_002851.2). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-ALDH18A1 antibody    (1ug/ml) staining of MCF7 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ALDH18A1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ALDH18A1 antibody    (0.3ug/ml) staining of NIH3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ALDH18A1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ALDH18A1. It may not necessarily be applicable to this product.
 NCBI GI #    21361368
 NCBI GeneID    5832
 NCBI Accession #    NP_002851.2 [Other Products]
 NCBI Related Accession #    NP_001017423.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002860.3 [Other Products]
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 UniProt Secondary Accession #    O95952; Q3KQU2; Q5T566; Q5T567; Q9UM72; B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44 [Other Products]
 UniProt Related Accession #    P54886 [Other Products]
 Molecular Weight    87,089 Da
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 NCBI Official Full Name    delta-1-pyrroline-5-carboxylate synthase isoform 1
 NCBI Official Synonym Full Names    aldehyde dehydrogenase 18 family member A1
 NCBI Official Symbol    ALDH18A1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    delta-1-pyrroline-5-carboxylate synthase
 UniProt Protein Name    Delta-1-pyrroline-5-carboxylate synthase
 UniProt Synonym Protein Names   
Aldehyde dehydrogenase family 18 member A1Including the following 2 domains:Glutamate 5-kinase (EC:; GKAlternative name(s):Gamma-glutamyl kinase
 UniProt Gene Name    ALDH18A1 [Similar Products]
 UniProt Synonym Gene Names    GSAS; P5CS; PYCS; P5CS; GK; GPR [Similar Products]
 UniProt Entry Name    P5CS_HUMAN
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 NCBI Summary for ALDH18A1    This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ALDH18A1    ALDH18A1: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. Defects in ALDH18A1 are the cause of cutis laxa, autosomal recessive, type 3A (ARCL3A). A syndrome characterized by facial dysmorphism with a progeroid appearance, large and late-closing fontanel, cutis laxa, joint hyperlaxity, athetoid movements and hyperreflexia, pre- and postnatal growth retardation, intellectual deficit, developmental delay, and ophthalmologic abnormalities. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Kinase, other; EC; Mitochondrial; EC; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion

Molecular Function: ATP binding; delta1-pyrroline-5-carboxylate synthetase activity; glutamate 5-kinase activity; glutamate-5-semialdehyde dehydrogenase activity; protein binding

Biological Process: amino acid biosynthetic process; citrulline biosynthetic process; glutamate metabolic process; ornithine biosynthetic process; phosphorylation; proline biosynthetic process

Disease: Cutis Laxa, Autosomal Dominant 3; Cutis Laxa, Autosomal Recessive, Type Iiia; Spastic Paraplegia 9a, Autosomal Dominant; Spastic Paraplegia 9b, Autosomal Recessive
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 Research Articles on ALDH18A1    1. Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ALDH18A1 antibodyDiseases associated with anti-ALDH18A1 antibody
 Products by Pathway  Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 L-citrulline Biosynthesis Pathway antibodies  L-citrulline Biosynthesis Pathway Diagram
 L-ornithine Biosynthesis II Pathway antibodies  L-ornithine Biosynthesis II Pathway Diagram
 L-proline Biosynthesis I Pathway antibodies  L-proline Biosynthesis I Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with ALDH18A1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with ALDH18A1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with ALDH18A1 and Heart Diseases
 Muscular Diseases Antibodies  >1 publications with ALDH18A1 and Muscular Diseases
 Heart Defects, Congenital Antibodies  >1 publications with ALDH18A1 and Heart Defects, Congenital
Organs/Tissues associated with anti-ALDH18A1 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >9 publications with ALDH18A1 and Skin
 Connective Tissue Antibodies  >4 publications with ALDH18A1 and Connective Tissue
 Brain Antibodies  >4 publications with ALDH18A1 and Brain
 Blood Antibodies  >3 publications with ALDH18A1 and Blood
 Vascular Antibodies  >2 publications with ALDH18A1 and Vascular
 Eye Antibodies  >2 publications with ALDH18A1 and Eye
 Heart Antibodies  >1 publications with ALDH18A1 and Heart
 Pancreas Antibodies  >1 publications with ALDH18A1 and Pancreas
 Intestine Antibodies  >1 publications with ALDH18A1 and Intestine
 Bone Antibodies  >1 publications with ALDH18A1 and Bone
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