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anti-ALDH1A3 antibody :: Rabbit anti-Human, Mouse ALDH1A3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7047656
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALDH1A3, Polyclonal Antibody

★Popular Item★
 Also Known As   

ALDH1A3 Antibody

 Product Synonym Names    Aldehyde dehydrogenase family 1 member A3; Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; ALDH1A3; ALDH6
 Product Gene Name   

anti-ALDH1A3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    U07919 mRNA
 3D Structure    ModBase 3D Structure for P47895
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Aldehyde dehydrogenase family 1 member A3 protein (2-210AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26712 / sc-26713
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ALDH1A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ALDH1A3 antibody

   Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
 Applications Tested/Suitable for anti-ALDH1A3 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-ALDH1A3 antibody    WB: 1: 2000-1: 10000
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-ALDH1A3 antibody    Western Blot
Positive WB detected in:U87 whole cell lysate,Mouse liver tissue
All lanes: ALDH1A3 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57 kDa
Observed band size: 57 kDa

anti-ALDH1A3 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-ALDH1A3 antibody    Immunofluorescent analysis of PC3 cells using MBS7047656 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ALDH1A3 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ALDH1A3. It may not necessarily be applicable to this product.
 NCBI GI #    153266822
 NCBI GeneID    220
 NCBI Accession #    NP_000684.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000693.3 [Other Products]
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 UniProt Primary Accession #    P47895 [Other Products]
 UniProt Secondary Accession #    Q6NT64 [Other Products]
 UniProt Related Accession #    P47895 [Other Products]
 Molecular Weight    56,108 Da
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 NCBI Official Full Name    aldehyde dehydrogenase family 1 member A3 isoform 1
 NCBI Official Synonym Full Names    aldehyde dehydrogenase 1 family member A3
 NCBI Official Symbol    ALDH1A3 [Similar Products]
 NCBI Official Synonym Symbols   
ALDH6; MCOP8; RALDH3; ALDH1A6
[Similar Products]
 NCBI Protein Information    aldehyde dehydrogenase family 1 member A3
 UniProt Protein Name    Aldehyde dehydrogenase family 1 member A3
 UniProt Synonym Protein Names   
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3
 Protein Family    Aldehyde dehydrogenase family
 UniProt Gene Name    ALDH1A3 [Similar Products]
 UniProt Synonym Gene Names    ALDH6; RALDH-3; RalDH3 [Similar Products]
 UniProt Entry Name    AL1A3_HUMAN
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 NCBI Summary for ALDH1A3    This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
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 UniProt Comments for ALDH1A3    ALDH1A3: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. Belongs to the aldehyde dehydrogenase family.

Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.5; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: cytoplasm; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; protein homodimerization activity; retinal dehydrogenase activity

Biological Process: embryonic eye morphogenesis; retinal metabolic process; retinoic acid metabolic process

Disease: Microphthalmia, Isolated 8
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 Research Articles on ALDH1A3    1. this report brings new information for the phenotype-genotype correlation of ALDH1A3 mutations and raises important questions, especially in terms of genetic counselling given to the patients and their families
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALDH1A3 antibodyPathways associated with anti-ALDH1A3 antibody
 Reference Product  PubMed Publications
 ADH7 antibody  >1 publications with ALDH1A3 and ADH7
 Products by Pathway  Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
Diseases associated with anti-ALDH1A3 antibodyOrgans/Tissues associated with anti-ALDH1A3 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >10 publications with ALDH1A3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >9 publications with ALDH1A3 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >7 publications with ALDH1A3 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >7 publications with ALDH1A3 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >7 publications with ALDH1A3 and Neoplasm Metastasis
 Lung Diseases Antibodies  >7 publications with ALDH1A3 and Lung Diseases
 Disease Models, Animal Antibodies  >4 publications with ALDH1A3 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >4 publications with ALDH1A3 and Neoplasms, Experimental
 Inflammation Antibodies  >4 publications with ALDH1A3 and Inflammation
 Abnormalities, Drug-Induced Antibodies  >3 publications with ALDH1A3 and Abnormalities, Drug-Induced
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >23 publications with ALDH1A3 and Eye
 Brain Antibodies  >15 publications with ALDH1A3 and Brain
 Lung Antibodies  >14 publications with ALDH1A3 and Lung
 Embryonic Tissue Antibodies  >9 publications with ALDH1A3 and Embryonic Tissue
 Liver Antibodies  >9 publications with ALDH1A3 and Liver
 Skin Antibodies  >8 publications with ALDH1A3 and Skin
 Thyroid Antibodies  >5 publications with ALDH1A3 and Thyroid
 Bone Antibodies  >5 publications with ALDH1A3 and Bone
 Mouth Antibodies  >5 publications with ALDH1A3 and Mouth
 Testis Antibodies  >5 publications with ALDH1A3 and Testis
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