NP_000681.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56.38 kDa
NCBI Official Full Name
aldehyde dehydrogenase, mitochondrial isoform 1
NCBI Official Synonym Full Names
aldehyde dehydrogenase 2 family (mitochondrial)
NCBI Protein Information
aldehyde dehydrogenase, mitochondrial
UniProt Protein Name
Aldehyde dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ALDH class 2; ALDH-E2; ALDHI
UniProt Synonym Gene Names
UniProt Entry Name
ALDH2_HUMAN
NCBI Summary for ALDH2
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
UniProt Comments for ALDH2
ALDH2: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
Protein type: Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - histidine; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - arginine and proline; Lipid Metabolism - glycerolipid; Mitochondrial; Oxidoreductase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - pyruvate; Amino Acid Metabolism - tryptophan; Lipid Metabolism - fatty acid; EC 1.2.1.3; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - ascorbate and aldarate
Chromosomal Location of Human Ortholog: 12q24.2
Cellular Component: mitochondrial matrix
Molecular Function: aldehyde dehydrogenase (NAD) activity; electron carrier activity; aldehyde dehydrogenase [NAD(P)+] activity
Biological Process: synaptic transmission; ethanol catabolic process; xenobiotic metabolic process; carbohydrate metabolic process; alcohol metabolic process; ethanol oxidation; neurotransmitter biosynthetic process
Disease: Alcohol Sensitivity, Acute
Research Articles on ALDH2
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Products associated with anti-ALDH2 antibody
Pathways associated with anti-ALDH2 antibody
Diseases associated with anti-ALDH2 antibody
Organs/Tissues associated with anti-ALDH2 antibody
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