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anti-ALG2 antibody :: Rabbit anti-Human ALG2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS415937
Western Blot (WB)
Unit / Price
0.1 mg  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALG2, Polyclonal Antibody

 Also Known As   

Anti-ALG2 Antibody

 Product Gene Name   

anti-ALG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607905
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity purified
 Form/Format    Liquid
 Concentration    100ug/100ul (lot specific)
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 Storage Buffer    PBS, pH 7.4 with 0.02% Sodium Azide
 Immunogen    Raised against a recombinate human ALG2 protein 118-374aa (BC017876).
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 Preparation and Storage    This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
 Other Notes    Small volumes of anti-ALG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ALG2 antibody

   Rabbit polyclonal ALG2
 Applications Tested/Suitable for anti-ALG2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ALG2 antibody    ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.
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 Western Blot (WB) of anti-ALG2 antibody    anti-ALG2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ALG2. It may not necessarily be applicable to this product.
 NCBI GI #    17389714
 NCBI GeneID    85365
 NCBI Accession #    BC017876 [Other Products]
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 UniProt Secondary Accession #    Q8NBX2; Q8NC39; A2A2Y0 [Other Products]
 UniProt Related Accession #    Q9H553 [Other Products]
 Molecular Weight    37,017 Da
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 NCBI Official Full Name    Homo sapiens asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae), mRNA
 NCBI Official Synonym Full Names    ALG2, alpha-1,3/1,6-mannosyltransferase
 NCBI Official Symbol    ALG2 [Similar Products]
 NCBI Official Synonym Symbols   
CDGIi; NET38; CMSTA3; hALPG2
[Similar Products]
 NCBI Protein Information    alpha-1,3/1,6-mannosyltransferase ALG2; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; alpha-1,3-mannosyltransferase ALG2; asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog; asparagine-linked glycosylation protein 2 homolog; homolog of yeast ALG2
 UniProt Protein Name    Alpha-1,3/1,6-mannosyltransferase ALG2
 UniProt Synonym Protein Names   
Asparagine-linked glycosylation protein 2 homolog; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
 Protein Family    Alpha-1,3/1,6-mannosyltransferase
 UniProt Gene Name    ALG2 [Similar Products]
 UniProt Entry Name    ALG2_HUMAN
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 NCBI Summary for ALG2    This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
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 UniProt Comments for ALG2    ALG2: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate. Defects in ALG2 are the cause of congenital disorder of glycosylation type 1I (CDG1I). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.1.257; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase; EC 2.4.1.132

Chromosomal Location of Human Ortholog: 9q22.33

Cellular Component: endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; cytoplasm; integral to membrane; nucleus

Molecular Function: protein binding; protein heterodimerization activity; glycolipid 3-alpha-mannosyltransferase activity; glycolipid 6-alpha-mannosyltransferase activity; alpha-1,3-mannosyltransferase activity; protein N-terminus binding; calcium-dependent protein binding

Biological Process: protein amino acid glycosylation in endoplasmic reticulum; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; response to calcium ion

Disease: Congenital Disorder Of Glycosylation, Type Ii; Myasthenic Syndrome, Congenital, With Tubular Aggregates 3
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Product References and Citations for anti-ALG2 antibody

   (1) Lim,Y., Mantalaris,A., Yap,M.G. and Wong,D.C. Simultaneous targeting of Requiem & Alg-2 in Chinese hamster ovary cells for improved recombinant protein production. Mol. Biotechnol. 46 (3), 301-307 (2010).
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 Research Articles on ALG2    1. ALG-2/Sec31A interactions were not required for the localization of Sec31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALG2 antibodyPathways associated with anti-ALG2 antibody
 Reference Product  PubMed Publications
 ALG1 antibody  >10 publications with ALG2 and ALG1
 ALG11 antibody  >2 publications with ALG2 and ALG11
 TSG101 antibody  >1 publications with ALG2 and TSG101
 PDCD6IP antibody  >1 publications with ALG2 and PDCD6IP
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies  Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
 Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway antibodies  Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway Diagram
 Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway antibodies  Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway Diagram
 Defective ALG12 Causes ALG12-CDG (CDG-1g) Pathway antibodies  Defective ALG12 Causes ALG12-CDG (CDG-1g) Pathway Diagram
 Defective ALG14 Causes Congenital Myasthenic Syndrome (ALG14-CMS) Pathway antibodies  Defective ALG14 Causes Congenital Myasthenic Syndrome (ALG14-CMS) Pathway Diagram
 Defective ALG2 Causes ALG2-CDG (CDG-1i) Pathway antibodies  Defective ALG2 Causes ALG2-CDG (CDG-1i) Pathway Diagram
 Defective ALG3 Causes ALG3-CDG (CDG-1d) Pathway antibodies  Defective ALG3 Causes ALG3-CDG (CDG-1d) Pathway Diagram
 Defective ALG6 Causes ALG6-CDG (CDG-1c) Pathway antibodies  Defective ALG6 Causes ALG6-CDG (CDG-1c) Pathway Diagram
 Defective ALG8 Causes ALG8-CDG (CDG-1h) Pathway antibodies  Defective ALG8 Causes ALG8-CDG (CDG-1h) Pathway Diagram
Diseases associated with anti-ALG2 antibodyOrgans/Tissues associated with anti-ALG2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with ALG2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with ALG2 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with ALG2 and Necrosis
 Fetal Death Antibodies  >1 publications with ALG2 and Fetal Death
 Anemia Antibodies  >1 publications with ALG2 and Anemia
 Seizures Antibodies  >1 publications with ALG2 and Seizures
 Hepatomegaly Antibodies  >1 publications with ALG2 and Hepatomegaly
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with ALG2 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with ALG2 and Brain
 Bone Antibodies  >2 publications with ALG2 and Bone
 Cervix Antibodies  >1 publications with ALG2 and Cervix
 Bone Marrow Antibodies  >1 publications with ALG2 and Bone Marrow
 Liver Antibodies  >1 publications with ALG2 and Liver
 Kidney Antibodies  >1 publications with ALG2 and Kidney
 Skin Antibodies  >1 publications with ALG2 and Skin
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