AAH04313.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,370 Da
NCBI Official Full Name
ALG3 protein, partial
NCBI Official Synonym Full Names
ALG3, alpha-1,3- mannosyltransferase
NCBI Official Synonym Symbols
CDG1D; CDGS4; Not56; NOT56L; D16Ertd36e [Similar Products]
NCBI Protein Information
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Not56-like protein; asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog; asparagine-linked glycosylation protein 3 homolog; carbohydrate deficient glycoprotein syndrome type IV; dol-P-Man dependent alpha(1-3)-mannosyltransferase; dol-P-Man dependent alpha-1,3- mannosyltransferase; dol-P-Man-dependent alpha(1-3)-mannosyltransferase; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
UniProt Protein Name
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
UniProt Synonym Protein Names
Asparagine-linked glycosylation protein 3 homolog; Dol-P-Man-dependent alpha(1-3)-mannosyltransferase; Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase; Not56-like protein
UniProt Synonym Gene Names
UniProt Entry Name
ALG3_HUMAN
NCBI Summary for ALG3
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
UniProt Comments for ALG3
ALG3: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in ALG3 are the cause of congenital disorder of glycosylation type 1D (CDG1D); also known as carbohydrate-deficient glycoprotein syndrome type IV (CDGS4). CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. Belongs to the glycosyltransferase 58 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; EC 2.4.1.258; Endoplasmic reticulum; Transferase; Membrane protein, multi-pass; Glycan Metabolism - N-glycan biosynthesis
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: alpha-1,3-mannosyltransferase activity
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Disease: Congenital Disorder Of Glycosylation, Type Id
Research Articles on ALG3
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Products associated with anti-ALG3 antibody
Pathways associated with anti-ALG3 antibody
Diseases associated with anti-ALG3 antibody
Organs/Tissues associated with anti-ALG3 antibody
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