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anti-ALG9 antibody :: Rabbit anti-Human ALG9 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9408242
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALG9, Polyclonal Antibody

★Popular Item★
 Also Known As   

ALG9 Antibody

 Product Synonym Names    CDG1L; DIBD1; LOH11CR1J
 Product Gene Name   

anti-ALG9 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606941
 3D Structure    ModBase 3D Structure for Q9H6U8
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody detects endogenous levels of total ALG9 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    2.2 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Fusion protein corresponding to a region derived from internal residues of human ALG9, alpha-1,2-mannosyltransferase
 Target Name    ALG9
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-ALG9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ALG9 antibody

   This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-ALG9 antibody    Total protein Ab
 Applications Tested/Suitable for anti-ALG9 antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-ALG9 antibody    Immunohistochemistry: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-ALG9 antibody    Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/60.
anti-ALG9 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ALG9 antibody    Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/60.
anti-ALG9 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ALG9. It may not necessarily be applicable to this product.
 NCBI GI #    118026933
 NCBI GeneID    79796
 NCBI Accession #    NP_001071158.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001077690.1 [Other Products]
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 UniProt Primary Accession #    Q9H6U8 [Other Products]
 UniProt Secondary Accession #    Q6ZMD5; Q7Z4R4; Q96GS7; Q96PB9; Q9H068 [Other Products]
 UniProt Related Accession #    Q9H6U8 [Other Products]
 Molecular Weight    51,743 Da
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 NCBI Official Full Name    alpha-1,2-mannosyltransferase ALG9 isoform b
 NCBI Official Synonym Full Names    ALG9, alpha-1,2-mannosyltransferase
 NCBI Official Symbol    ALG9 [Similar Products]
 NCBI Official Synonym Symbols   
CDG1L; DIBD1; LOH11CR1J
[Similar Products]
 NCBI Protein Information    alpha-1,2-mannosyltransferase ALG9
 UniProt Protein Name    Alpha-1,2-mannosyltransferase ALG9
 UniProt Synonym Protein Names   
Asparagine-linked glycosylation protein 9 homolog; Disrupted in bipolar disorder protein 1; Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
 Protein Family    Alpha-1,2-mannosyltransferase
 UniProt Gene Name    ALG9 [Similar Products]
 UniProt Synonym Gene Names    DIBD1 [Similar Products]
 UniProt Entry Name    ALG9_HUMAN
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 NCBI Summary for ALG9    This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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 UniProt Comments for ALG9    ALG9: Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. A chromosomal aberration involving ALG9 is found in a family with bipolar affective disorder. Translocation t(9;11)(p24;q23). However, common variations in ALG9 do not play a major role in predisposition to bipolar affective disorder. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase 22 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - N-glycan biosynthesis; Transferase; EC 2.4.1.259; Membrane protein, multi-pass; Membrane protein, integral; EC 2.4.1.261

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: mannosyltransferase activity

Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

Disease: Congenital Disorder Of Glycosylation, Type Il
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 Research Articles on ALG9    1. Due to the ALG9 deficiency, cells accumulated the lipid-linked oligosaccharides Man(6)GlcNAc(2)-PP-dolichol and Man(8)GlcNAc(2)-PP-dolichol.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALG9 antibodyPathways associated with anti-ALG9 antibody
 Reference Product  PubMed Publications
 ALG12 antibody  >8 publications with ALG9 and ALG12
 ALG3 antibody  >5 publications with ALG9 and ALG3
 ALG6 antibody  >3 publications with ALG9 and ALG6
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies  Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycan Precursor Biosynthesis Pathway antibodies  N-glycan Precursor Biosynthesis Pathway Diagram
 N-glycan Precursor Biosynthesis Pathway antibodies  N-glycan Precursor Biosynthesis Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with anti-ALG9 antibodyOrgans/Tissues associated with anti-ALG9 antibody
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >7 publications with ALG9 and Metabolic Diseases
 Hepatomegaly Antibodies  >3 publications with ALG9 and Hepatomegaly
 Nervous System Diseases Antibodies  >3 publications with ALG9 and Nervous System Diseases
 Adenocarcinoma Antibodies  >2 publications with ALG9 and Adenocarcinoma
 Inflammation Antibodies  >1 publications with ALG9 and Inflammation
 Liver Neoplasms Antibodies  >1 publications with ALG9 and Liver Neoplasms
 Hypertrophy Antibodies  >1 publications with ALG9 and Hypertrophy
 Congenital disorder of glycosylation type 1L Antibodies  >1 publications with ALG9 and Congenital disorder of glycosylation type 1L
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with ALG9 and Brain
 Muscle Antibodies  >3 publications with ALG9 and Muscle
 Stomach Antibodies  >2 publications with ALG9 and Stomach
 Blood Antibodies  >2 publications with ALG9 and Blood
 Pancreas Antibodies  >1 publications with ALG9 and Pancreas
 Liver Antibodies  >1 publications with ALG9 and Liver
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