NP_001194.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,582 Da
NCBI Official Full Name
bone morphogenetic protein receptor type-1B isoform b
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 1B
NCBI Official Synonym Symbols
ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293 [Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-1B
UniProt Protein Name
Bone morphogenetic protein receptor type-1B
UniProt Synonym Protein Names
CD_antigen: CDw293
UniProt Synonym Gene Names
NCBI Summary for ALK-6/BMPR1B
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for ALK-6/BMPR1B
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Research Articles on ALK-6/BMPR1B
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Products associated with anti-ALK-6/BMPR1B antibody
Pathways associated with anti-ALK-6/BMPR1B antibody
Diseases associated with anti-ALK-6/BMPR1B antibody
Organs/Tissues associated with anti-ALK-6/BMPR1B antibody
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