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anti-ALK antibody :: Rabbit ALK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175323
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALK, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-ALK antibody

 Product Synonym Names    ALK tyrosine kinase receptor; anaplastic lymphoma receptor tyrosine kinase; Alk antibody; ALK tyrosine kinase receptor antibody; ALK tyrosine kinase receptor precursor antibody; ALK/EML4 fusion gene, included antibody; ALK/NPM1 fusion gene, included antibody; ALK_HUMAN antibody; anaplastic lymphoma kinase(Ki-1) antibody; Anaplastic lymphoma kinase antibody; Anaplastic lymphoma kinase Ki 1 antibody; Anaplastic lymphoma kinase Ki1 antibody; Anaplastic lymphoma kinase p80 antibody; anaplastic lymphoma receptor tyrosine kinase antibody; CD 246 antibody; CD246 antibody; CD246 antigen antibody; EC 2.7.10.1 antibody; Ki 1 antibody; Ki1 antibody; mutant anaplastic lymphoma kinase antibody; NBLST 3 antibody; NBLST3 antibody; Tcrz antibody; TFG/ALK antibody
 Product Gene Name   

anti-ALK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613014
 3D Structure    ModBase 3D Structure for Q9UM73
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human ALK (1571-1589aa LFRLRHFPCGNVNYGYQQQ), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ALK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ALK antibody

   Description: Rabbit IgG polyclonal antibody for ALK tyrosine kinase receptor(ALK) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: ALK(Anaplastic lymphoma kinase) also known as ALK tyrosine kinase receptor or CD246(cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. The ALK gene is mapped on 2p23.2-p23.1. Expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. The deduced amino acid sequences reveal that ALK is a novel receptor tyrosine kinase having a putative transmembrane domain and an extracellular domain. In Drosophila, localized Jeb activates Alk and the downstream Ras/mitogen-activated protein kinase cascade to specify a select group of visceral muscle precursors as muscle-patterning pioneers. Functional RNA interference screening on a set of these transcriptional targets revealed that CEBPB and BCL2A1 were absolutely necessary to induce cell transformation and/or to sustain growth and survival of ALK-positive ALCL cells. One particularly informative case presented a high-level gene amplification that was strictly limited to ALK, indicating that this gene may contribute on its own to neuroblastoma development. Mutated ALK proteins were overexpressed, hyperphosphorylated, and showed constitutive kinase activity. The knockdown of ALK expression in ALK-mutated cells, but also in cell lines overexpressing a wildtype ALK, led to a marked decrease of cell proliferation.
 Applications Tested/Suitable for anti-ALK antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Western Blot (WB) of anti-ALK antibody    Anti-ALK antibody, MBS175323, Western blotting
Lane 1: Rat Brain Tissue Lysate
Lane 2: Rat Testis Tissue Lysate
Lane 3: U87 Cell Lysate
Lane 4: HELA Cell Lysate
Lane 5: COLO320 Cell Lysate
Lane 6: JURKAT Cell Lysate

anti-ALK antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ALK antibody    Anti-ALK antibody, MBS175323, IHC(P)
IHC(P): Rat Intestine Tissue
anti-ALK antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ALK antibody    Anti-ALK antibody, MBS175323, IHC(P)
IHC(P): Human Rectal Cancer Tissue
anti-ALK antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ALK. It may not necessarily be applicable to this product.
 NCBI GI #    296439447
 NCBI GeneID    238
 NCBI Accession #    Q9UM73.3 [Other Products]
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 UniProt Primary Accession #    Q9UM73 [Other Products]
 UniProt Secondary Accession #    Q4ZFX9; Q53QQ6; Q53RZ4; Q59FI3; Q9Y4K6 [Other Products]
 UniProt Related Accession #    Q9UM73 [Other Products]
 Molecular Weight    176,442 Da
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 NCBI Official Full Name    ALK tyrosine kinase receptor
 NCBI Official Synonym Full Names    anaplastic lymphoma receptor tyrosine kinase
 NCBI Official Symbol    ALK [Similar Products]
 NCBI Official Synonym Symbols   
CD246; NBLST3
[Similar Products]
 NCBI Protein Information    ALK tyrosine kinase receptor; CD246 antigen; mutant anaplastic lymphoma kinase
 UniProt Protein Name    ALK tyrosine kinase receptor
 UniProt Synonym Protein Names   
Anaplastic lymphoma kinase; CD_antigen: CD246
 Protein Family    Alkylsulfatase
 UniProt Gene Name    ALK [Similar Products]
 UniProt Entry Name    ALK_HUMAN
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 NCBI Summary for ALK    This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
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 UniProt Comments for ALK    ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors

Protein type: Kinase, protein; EC 2.7.10.1; Oncoprotein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Alk family

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: protein complex; integral to plasma membrane

Molecular Function: NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: regulation of apoptosis; cell proliferation; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; neuron development; signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; activation of NF-kappaB transcription factor

Disease: Neuroblastoma, Susceptibility To, 3
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 Research Articles on ALK    1. ALK rearrangement is associated with crizotinib responsiveness in non-small-cell lung cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALK antibodyPathways associated with anti-ALK antibody
 Reference Product  PubMed Publications
 STAT3 antibody  >91 publications with ALK and STAT3
 PTN antibody  >24 publications with ALK and PTN
 JAK3 antibody  >15 publications with ALK and JAK3
 NPM1 antibody  >14 publications with ALK and NPM1
 PHOX2B antibody  >11 publications with ALK and PHOX2B
 ZC3HC1 antibody  >5 publications with ALK and ZC3HC1
 SHC1 antibody  >4 publications with ALK and SHC1
 IRS1 antibody  >2 publications with ALK and IRS1
 HNRNPD antibody  >1 publications with ALK and HNRNPD
 Products by Pathway  Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
Diseases associated with anti-ALK antibodyOrgans/Tissues associated with anti-ALK antibody
 Disease Name  Pubmed Publications
 Lymphoma, Large-Cell, Anaplastic Antibodies  >1015 publications with ALK and Lymphoma, Large-Cell, Anaplastic
 Lung Diseases Antibodies  >786 publications with ALK and Lung Diseases
 Carcinoma, Non-Small-Cell Lung Antibodies  >515 publications with ALK and Carcinoma, Non-Small-Cell Lung
 Lymphoma, Large B-Cell, Diffuse Antibodies  >337 publications with ALK and Lymphoma, Large B-Cell, Diffuse
 Chromosome Aberrations Antibodies  >302 publications with ALK and Chromosome Aberrations
 Neuroblastoma Antibodies  >167 publications with ALK and Neuroblastoma
 Neoplasms, Experimental Antibodies  >114 publications with ALK and Neoplasms, Experimental
 Inflammation Antibodies  >109 publications with ALK and Inflammation
 Cell Transformation, Neoplastic Antibodies  >108 publications with ALK and Cell Transformation, Neoplastic
 Skin Neoplasms Antibodies  >91 publications with ALK and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >661 publications with ALK and Blood
 Muscle Antibodies  >261 publications with ALK and Muscle
 Brain Antibodies  >220 publications with ALK and Brain
 Liver Antibodies  >210 publications with ALK and Liver
 Connective Tissue Antibodies  >42 publications with ALK and Connective Tissue
 Spleen Antibodies  >36 publications with ALK and Spleen
 Stomach Antibodies  >27 publications with ALK and Stomach
 Testis Antibodies  >21 publications with ALK and Testis
 Trachea Antibodies  >2 publications with ALK and Trachea
 Uncharacterized Tissue Antibodies  >1 publications with ALK and Uncharacterized Tissue
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