NP_004295.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
176,442 Da
NCBI Official Full Name
ALK tyrosine kinase receptor
NCBI Official Synonym Full Names
anaplastic lymphoma receptor tyrosine kinase
NCBI Protein Information
ALK tyrosine kinase receptor
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Synonym Protein Names
Anaplastic lymphoma kinase; CD_antigen: CD246
UniProt Entry Name
ALK_HUMAN
NCBI Summary for ALK
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
UniProt Comments for ALK
ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors
Protein type: Protein kinase, tyrosine (receptor); Oncoprotein; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; TK group; Alk family
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: protein complex; integral to plasma membrane
Molecular Function: NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: regulation of apoptosis; cell proliferation; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; neuron development; signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; activation of NF-kappaB transcription factor
Disease: Neuroblastoma, Susceptibility To, 3
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Products associated with anti-ALK antibody
Pathways associated with anti-ALK antibody
Diseases associated with anti-ALK antibody
Disease Name |
Pubmed Publications |
Lymphoma, Large-Cell, Anaplastic Antibodies |
>1133 publications with ALK and Lymphoma, Large-Cell, Anaplastic |
Respiratory Tract Diseases Antibodies |
>1122 publications with ALK and Respiratory Tract Diseases |
Lung Diseases Antibodies |
>1047 publications with ALK and Lung Diseases |
Lung Neoplasms Antibodies |
>1027 publications with ALK and Lung Neoplasms |
Carcinoma, Non-Small-Cell Lung Antibodies |
>680 publications with ALK and Carcinoma, Non-Small-Cell Lung |
Lymphoma, Large B-Cell, Diffuse Antibodies |
>349 publications with ALK and Lymphoma, Large B-Cell, Diffuse |
Chromosome Aberrations Antibodies |
>344 publications with ALK and Chromosome Aberrations |
Neuroblastoma Antibodies |
>192 publications with ALK and Neuroblastoma |
Neoplasms, Experimental Antibodies |
>131 publications with ALK and Neoplasms, Experimental |
Inflammation Antibodies |
>131 publications with ALK and Inflammation |
Organs/Tissues associated with anti-ALK antibody
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