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anti-ALKBH3 antibody :: Rabbit anti-Human ALKBH3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6008988 anti-ALKBH3 antibody
Unit / Price
0.1 mL  /  $560 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALKBH3, Polyclonal Antibody

 Also Known As   

ALKBH3 (Alpha-ketoglutarate-dependent Dioxygenase alkB Homolog 3, ABH3, AlkB Homolog 3, Alkylated DNA Repair Protein alkB Homolog 3, Alkylation Repair Homolog 3, DEPC1, DEPC-1, FLJ43614, MGC118790, MGC118792, MGC118793, Prostate Cancer Antigen 1, PCA1)

 Product Synonym Names    Anti -ALKBH3 (Alpha-ketoglutarate-dependent Dioxygenase alkB Homolog 3, ABH3, AlkB Homolog 3, Alkylated DNA Repair Protein alkB Homolog 3, Alkylation Repair Homolog 3, DEPC1, DEPC-1, FLJ43614, MGC118790, MGC118792, MGC118793, Prostate Cancer Antigen 1, PCA1)
 Product Gene Name   

anti-ALKBH3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    MEEKRRRARV QGAWAAPVKS QAIAQPATTA KSHLHQKPGQ TWKNKEHHLS DREFVFKEPQ QVVRRAPEPR VIDREGVYEI SLSPTGVSRV CLYPGFVDVK EADWILEQLC QDVPWKQRTG IREDITYQQP RLTAWYGELP YTYSRITMEP NPHWHPVLRT LKNRIEENTG HTFNSLLCNL YRNEKDSVDW HSDDEPSLGR CPIIASLSFG ATRTFEMRKK PPPEENGEYT YVERVKIPLD HGTLLIMEGA TQADWQHRVP KEYHSREPRV NLTFRTVYPD PRGAPW
 Chromosome Location    Chromosome: 11; NC_000011.9 (43902357..43941825). Location: 11p11.2
 OMIM    610603
 3D Structure    ModBase 3D Structure for Q96Q83
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human ALKBH3.
 Purity/Purification    Serum
Serum
 Form/Format    Supplied as a liquid.
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 Immunogen    Full length human ALKBH3, aa1-286 (AAI03813.1).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ALKBH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ALKBH3 antibody

   ALKBH3 is a member of the ALKB family of proteins and functions as a dioxygenase with a preference for RNA and single stranded DNA substrates. This protein repairs 1-methyladenine and 3-methylcytosine lesions in alkylated DNA and RNA and its activity is stimulated by ascorbate. ALKBH3 is expressed in a wide variety of tissues and localizes to the cytoplasm and the nucleus.
 Product Categories/Family for anti-ALKBH3 antibody    Antibodies; Abs to DNA Repair/Damage
 Applications Tested/Suitable for anti-ALKBH3 antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-ALKBH3 antibody    Suitable for use in Western Blot and Immunoprecipitation.
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NCBI/Uniprot data below describe general gene information for ALKBH3. It may not necessarily be applicable to this product.
 NCBI GI #    21040275
 NCBI GeneID    221120
 NCBI Accession #    NP_631917.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_139178.3 [Other Products]
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 UniProt Primary Accession #    Q96Q83 [Other Products]
 UniProt Secondary Accession #    Q3SYI0; Q6NX57; Q96BU8; A6NDJ1 [Other Products]
 UniProt Related Accession #    Q96Q83 [Other Products]
 Molecular Weight    33,375 Da [Similar Products]
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 NCBI Official Full Name    alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
 NCBI Official Synonym Full Names    alkB, alkylation repair homolog 3 (E. coli)
 NCBI Official Symbol    ALKBH3 [Similar Products]
 NCBI Official Synonym Symbols   
ABH3; PCA1; DEPC1; DEPC-1
[Similar Products]
 NCBI Protein Information    alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; prostate cancer antigen 1; prostate cancer antigen-1; alkylated DNA repair protein alkB homolog 3
 UniProt Protein Name    Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
 UniProt Synonym Protein Names   
Alkylated DNA repair protein alkB homolog 3; DEPC-1; Prostate cancer antigen 1
 Protein Family    Alpha-ketoglutarate-dependent dioxygenase
 UniProt Gene Name    ALKBH3 [Similar Products]
 UniProt Synonym Gene Names    ABH3; DEPC1 [Similar Products]
 UniProt Entry Name    ALKB3_HUMAN
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 NCBI Summary for ALKBH3    The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for ALKBH3    ALKBH3: Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; Oxidoreductase; EC 1.14.11.-; Hydrolase; Demethylase

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function: protein binding; L-ascorbic acid binding; ferrous iron binding; DNA-N1-methyladenine dioxygenase activity; DNA demethylase activity

Biological Process: cell proliferation; DNA dealkylation; DNA repair
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 Research Articles on ALKBH3    1. ALKBH3 contributes to development of urothelial carcinomas by accelerating their survival, angiogenesis, and invasion
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALKBH3 antibodyPathways associated with anti-ALKBH3 antibody
 Reference Product  PubMed Publications
 ALKBH1 antibody  >6 publications with ALKBH3 and ALKBH1
 FTO antibody  >2 publications with ALKBH3 and FTO
 ALKBH4 antibody  >1 publications with ALKBH3 and ALKBH4
 ALKBH8 antibody  >1 publications with ALKBH3 and ALKBH8
 Products by Pathway  Pathway Diagram
 ABH3 Mediated Reversal Of Alkylation Damage Pathway antibodies  ABH3 Mediated Reversal Of Alkylation Damage Pathway Diagram
 DNA Damage Reversal Pathway antibodies  DNA Damage Reversal Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Reversal Of Alkylation Damage By DNA Dioxygenases Pathway antibodies  Reversal Of Alkylation Damage By DNA Dioxygenases Pathway Diagram
Diseases associated with anti-ALKBH3 antibodyOrgans/Tissues associated with anti-ALKBH3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with ALKBH3 and Neoplasms
 Hyperplasia Antibodies  >1 publications with ALKBH3 and Hyperplasia
 Obesity Antibodies  >1 publications with ALKBH3 and Obesity
 Inflammation Antibodies  >1 publications with ALKBH3 and Inflammation
 Respiratory Tract Diseases Antibodies  >1 publications with ALKBH3 and Respiratory Tract Diseases
 Necrosis Antibodies  >1 publications with ALKBH3 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >2 publications with ALKBH3 and Prostate
 Bladder Antibodies  >1 publications with ALKBH3 and Bladder
 Pancreas Antibodies  >1 publications with ALKBH3 and Pancreas
 Intestine Antibodies  >1 publications with ALKBH3 and Intestine
 Lung Antibodies  >1 publications with ALKBH3 and Lung
 Brain Antibodies  >1 publications with ALKBH3 and Brain
 Vascular Antibodies  >1 publications with ALKBH3 and Vascular
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