NP_000688.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,694 Da
NCBI Official Full Name
arachidonate 12-lipoxygenase, 12S-type
NCBI Official Synonym Full Names
arachidonate 12-lipoxygenase
NCBI Protein Information
arachidonate 12-lipoxygenase, 12S-type; platelet 12-LOX; 12S-lipoxygenase; platelet-type 12-lipoxygenase; platelet-type lipoxygenase 12
UniProt Protein Name
Arachidonate 12-lipoxygenase, 12S-type
UniProt Synonym Protein Names
Platelet-type lipoxygenase 12
UniProt Synonym Gene Names
UniProt Entry Name
LOX12_HUMAN
UniProt Comments for ALOX12
ALOX12: Oxygenase and 14,15-leukotriene A4 synthase activity. Belongs to the lipoxygenase family.
Protein type: Lipid Metabolism - arachidonic acid; EC 1.13.11.31; Apoptosis; Oxidoreductase
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: membrane; cytoplasm; cytosol; sarcolemma
Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding; hepoxilin A3 synthase activity; arachidonate 12-lipoxygenase activity; lipoxygenase activity; hepoxilin-epoxide hydrolase activity; iron ion binding
Biological Process: positive regulation of cell adhesion; positive regulation of smooth muscle cell proliferation; linoleic acid metabolic process; positive regulation of caspase activity; positive regulation of vasodilation; positive regulation of cell growth; positive regulation of angiogenesis; positive regulation of endothelial cell differentiation; positive regulation of mitochondrial depolarization; lipoxygenase pathway; positive regulation of cell proliferation; arachidonic acid metabolic process; fatty acid oxidation; hepoxilin biosynthetic process; cell motility; superoxide release; hepoxilin metabolic process; positive regulation of cell migration; aging; negative regulation of apoptosis
Product References and Citations for anti-ALOX12 antibody
1. Funk, C. D., Furci, L., FitzGerald, G. A.Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.Proc. Nat. Acad. Sci. 87: 5638-5642, 1990. 2. Natarajan, R., Esworthy, R., Bai, W., Gu, J.-L., Wilczynski, S., Nadler, J.Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor.J. Clin. Endocr. Metab. 82: 1790-1798, 1997. 3. Yoshimoto, T., Arakawa, T., Hada, T., Yamamoto, S., Takahashi, E.Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.J. Biol. Chem. 267: 24805-24809, 1992.
Research Articles on ALOX12
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Products associated with anti-ALOX12 antibody
Pathways associated with anti-ALOX12 antibody
Diseases associated with anti-ALOX12 antibody
Organs/Tissues associated with anti-ALOX12 antibody
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