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anti-ALOX15 antibody :: Goat anti-Human ALOX15 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS622181 anti-ALOX15 antibody
Unit / Price
0.1 mg  /  $560 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALOX15, Polyclonal Antibody

 Also Known As   

ALOX15 (Arachidonate 15-lipoxygenase, 15-LOX-1, 15-LOX2)

 Product Synonym Names    Anti -ALOX15 (Arachidonate 15-lipoxygenase, 15-LOX-1, 15-LOX2)
 Product Gene Name   

anti-ALOX15 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (4534214..4544960, complement). Location: 17p13.3
 OMIM    152392
 3D Structure    ModBase 3D Structure for P16050
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Human
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 Specificity    Recognizes human ALOX15.
 Purity/Purification    Affinity Purified
Purified by affinity chromatography.
 Form/Format    Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
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 Immunogen    A synthetic peptide from the C-terminus of aa-HYKTDVAVKDDPE.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ALOX15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ALOX15 antibody    Antibodies; Abs to Leukotrienes
 Applications Tested/Suitable for anti-ALOX15 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-ALOX15 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Peptide ELISA: 1:32,000.
Western Blot: 0.2-0.5µg/ml. Approx. 80kDa band observed in nuclear lysates of cell line HeLa (calculated MW of 74.8kDa according to NP_001131.3). Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for ALOX15. It may not necessarily be applicable to this product.
 NCBI GI #    40316937
 NCBI GeneID    246
 NCBI Accession #    NP_001131.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001140.3 [Other Products]
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 UniProt Primary Accession #    P16050 [Other Products]
 UniProt Secondary Accession #    Q8N6R7; Q99657; A8K2P4 [Other Products]
 UniProt Related Accession #    P16050; Q12938 [Other Products]
 Molecular Weight    74,804 Da [Similar Products]
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 NCBI Official Full Name    arachidonate 15-lipoxygenase
 NCBI Official Synonym Full Names    arachidonate 15-lipoxygenase
 NCBI Official Symbol    ALOX15 [Similar Products]
 NCBI Official Synonym Symbols   
15LOX-1; 15-LOX-1
[Similar Products]
 NCBI Protein Information    arachidonate 15-lipoxygenase; 15-LOX; 15-lipooxygenase-1; OTTHUMP00000115936; arachidonate omega-6 lipoxygenase
 UniProt Protein Name    Arachidonate 15-lipoxygenase
 UniProt Synonym Protein Names   
Arachidonate omega-6 lipoxygenase
 UniProt Gene Name    ALOX15 [Similar Products]
 UniProt Synonym Gene Names    LOG15 [Similar Products]
 UniProt Entry Name    LOX15_HUMAN
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 UniProt Comments for ALOX15    ALOX15: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid. Belongs to the lipoxygenase family.

Protein type: Lipid Metabolism - linoleic acid; Oxidoreductase; Motility/polarity/chemotaxis; Lipid Metabolism - arachidonic acid; EC 1.13.11.33; EC 1.13.11.31

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: extrinsic to internal side of plasma membrane; membrane; plasma membrane; lipid particle; cytosol

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; hepoxilin A3 synthase activity; arachidonate 12-lipoxygenase activity; arachidonate 15-lipoxygenase activity; hepoxilin-epoxide hydrolase activity; iron ion binding

Biological Process: ossification; positive regulation of heterotypic cell-cell adhesion; wound healing; phosphatidylethanolamine biosynthetic process; leukotriene metabolic process; bone mineralization; lipoxygenase pathway; positive regulation of actin filament polymerization; negative regulation of adaptive immune response; arachidonic acid metabolic process; hepoxilin biosynthetic process; inflammatory response; apoptotic cell clearance
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 Research Articles on ALOX15    1. Genetic absence of this enzyme results in a significant reduction in amyloid-beta (Abeta) production and deposition and an improvement of cognitive deficits.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ALOX15 antibodyDiseases associated with anti-ALOX15 antibody
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Linoleic Acid Metabolism Pathway antibodies  Linoleic Acid Metabolism Pathway Diagram
 Linoleic Acid Metabolism Pathway antibodies  Linoleic Acid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >145 publications with ALOX15 and Inflammation
 Neoplasms Antibodies  >127 publications with ALOX15 and Neoplasms
 Atherosclerosis Antibodies  >123 publications with ALOX15 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >95 publications with ALOX15 and Cardiovascular Diseases
 Asthma Antibodies  >47 publications with ALOX15 and Asthma
 Colorectal Neoplasms Antibodies  >40 publications with ALOX15 and Colorectal Neoplasms
 Intestinal Diseases Antibodies  >40 publications with ALOX15 and Intestinal Diseases
 Intestinal Neoplasms Antibodies  >37 publications with ALOX15 and Intestinal Neoplasms
 Hypersensitivity Antibodies  >34 publications with ALOX15 and Hypersensitivity
 Prostatic Neoplasms Antibodies  >31 publications with ALOX15 and Prostatic Neoplasms
Organs/Tissues associated with anti-ALOX15 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >85 publications with ALOX15 and Lung
 Prostate Antibodies  >40 publications with ALOX15 and Prostate
 Trachea Antibodies  >17 publications with ALOX15 and Trachea
 Embryonic Tissue Antibodies  >7 publications with ALOX15 and Embryonic Tissue
 Adipose Tissue Antibodies  >6 publications with ALOX15 and Adipose Tissue
 Placenta Antibodies  >6 publications with ALOX15 and Placenta
 Lymph Node Antibodies  >6 publications with ALOX15 and Lymph Node
 Testis Antibodies  >3 publications with ALOX15 and Testis
 Mouth Antibodies  >2 publications with ALOX15 and Mouth
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