NP_001034220.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,523 Da
NCBI Official Full Name
arachidonate 15-lipoxygenase B isoform b
NCBI Official Synonym Full Names
arachidonate 15-lipoxygenase, type B
NCBI Official Synonym Symbols
NCBI Protein Information
arachidonate 15-lipoxygenase B; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenase 2; arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; arachidonate omega(6) lipoxygenase; linoleate 13-lipoxygenase 15-LOb
UniProt Protein Name
Arachidonate 15-lipoxygenase B
UniProt Synonym Protein Names
15-lipoxygenase 2; 15-LOX-2; Arachidonate 15-lipoxygenase type II; Linoleate 13-lipoxygenase 15-LOb (EC:1.13.11.-)
UniProt Synonym Gene Names
UniProt Entry Name
LX15B_HUMAN
NCBI Summary for ALOX15B
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for ALOX15B
ALOX15B: Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized. Belongs to the lipoxygenase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.13.11.33; Apoptosis; Cell cycle regulation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoskeleton; extrinsic to membrane; membrane; cytoplasm; plasma membrane; intracellular; nucleus; cytosol
Molecular Function: arachidonate 15-lipoxygenase activity; lipoxygenase activity; iron ion binding; calcium ion binding; lipid binding
Biological Process: prostate gland development; apoptosis; linoleic acid metabolic process; negative regulation of cell cycle; negative regulation of cell proliferation; lipoxygenase pathway; regulation of epithelial cell differentiation; arachidonic acid metabolic process; lipid metabolic process; hepoxilin biosynthetic process; negative regulation of cell migration; positive regulation of keratinocyte differentiation; negative regulation of growth
Research Articles on ALOX15B
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Products associated with anti-ALOX15B antibody
Pathways associated with anti-ALOX15B antibody
Diseases associated with anti-ALOX15B antibody
Organs/Tissues associated with anti-ALOX15B antibody
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