NP_001191335.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
arachidonate 5-lipoxygenase-activating protein isoform 2
NCBI Official Synonym Full Names
arachidonate 5-lipoxygenase-activating protein
NCBI Official Synonym Symbols
NCBI Protein Information
arachidonate 5-lipoxygenase-activating protein; OTTHUMP00000018204; MK-886-binding protein
UniProt Protein Name
Arachidonate 5-lipoxygenase-activating protein
UniProt Synonym Protein Names
FLAP; MK-886-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
AL5AP_HUMAN
NCBI Summary for ALOX5AP
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
UniProt Comments for ALOX5AP
ALOX5AP: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Belongs to the MAPEG family.
Protein type: Nuclear envelope; Membrane protein, integral; Endoplasmic reticulum; Activator; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: endoplasmic reticulum membrane; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear envelope
Molecular Function: arachidonic acid binding; protein binding; glutathione transferase activity; leukotriene-C4 synthase activity; enzyme activator activity; protein N-terminus binding; glutathione peroxidase activity
Biological Process: leukotriene biosynthetic process; positive regulation of catalytic activity; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process
Disease: Stroke, Ischemic
Research Articles on ALOX5AP
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Products associated with anti-ALOX5AP antibody
Pathways associated with anti-ALOX5AP antibody
Diseases associated with anti-ALOX5AP antibody
Organs/Tissues associated with anti-ALOX5AP antibody
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