NP_001191335.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 18 kDa Predicted: 19 kDa
NCBI Official Full Name
arachidonate 5-lipoxygenase-activating protein isoform 2
NCBI Official Synonym Full Names
arachidonate 5-lipoxygenase activating protein
NCBI Official Synonym Symbols
NCBI Protein Information
arachidonate 5-lipoxygenase-activating protein
UniProt Protein Name
Arachidonate 5-lipoxygenase-activating protein
UniProt Synonym Protein Names
FLAP; MK-886-binding protein
UniProt Synonym Gene Names
NCBI Summary for ALOX5AP
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for ALOX5AP
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Research Articles on ALOX5AP
Precautions
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Products associated with anti-ALOX5AP antibody
Pathways associated with anti-ALOX5AP antibody
Diseases associated with anti-ALOX5AP antibody
Organs/Tissues associated with anti-ALOX5AP antibody
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