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anti-Snca antibody :: Rabbit ALPHA SYNUCLEIN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS222961 anti-Snca antibody
Unit / Price
0.1 mL  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALPHA SYNUCLEIN (Snca), Polyclonal Antibody

 Also Known As   

RABBIT ANTI RAT ALPHA SYNUCLEIN (pSer129)

 Product Gene Name   

anti-Snca antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P37377
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Bovine (Expected from Sequence), Dog (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence)
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 Specificity    This item specifically recognises rat alpha synuclein when phosphorylated at Ser129. Alpha synuclein is a 140 amino acid, 15kDa protein seen predominantly in the neocortex, hippocampus, substantia nigra, thalamus and cerebellum. Its normal cellular function has not been definitively determined, but it is thought to be involved in the regulation of neuronal plasticity, dopamine neurotransmission and other membrane-associated processes at the presynaptic terminal. Alpha synuclein is normally a soluble, unfolded protein, but it can aggregate at high concentrations to form insoluble fibrils which, in association with other proteins such as ubiquitin, neurofilament protein and alpha B crystalline, form Lewy bodies. Lewy bodies are a hallmark pathological feature of Parkinson's disease and other neurodegenerative diseases. Alpha synuclein has several possible phosphorylation sites, Ser129 in particular can be phosphorylated by G-protein-coupled receptor kinases. Studies suggest that this phosphorylation promotes formation of alpha synuclein filaments, with hyperphosphorylation of Ser129 seen in Lewy bodies.
 Form/Format    Purified
Purified IgG - liquid
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
50% Glycerol
0.01% Bovine Serum Albumin
 Immunogen    Synthetic phosphopeptide corresponding to amino acid sequence surrounding phosphorylated serine 129 of Alpha Synuclein.
Buffer Solution
 Antiserum Preparation    Antisera to Alpha Synulein (pSer129) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
 Target Species    Rat
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-Snca antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Snca antibody

   MBS222961 specifically recognises rat alpha synuclein when phosphorylated at Ser129. Alpha synuclein is a 140 amino acid, 15kDa protein seen predominantly in the neocortex, hippocampus, substantia nigra, thalamus and cerebellum. Its normal cellular function has not been definitively determined, but it is thought to be involved in the regulation of neuronal plasticity, dopamine neurotransmission and other membrane-associated processes at the presynaptic terminal. Alpha synuclein is normally a soluble, unfolded protein, but it can aggregate at high concentrations to form insoluble fibrils which, in association with other proteins such as ubiquitin, neurofilament protein and alpha B crystalline, form Lewy bodies. Lewy bodies are a hallmark pathological feature of Parkinson's disease and other neurodegenerative diseases. Alpha synuclein has several possible phosphorylation sites, Ser129 in particular can be phosphorylated by G-protein-coupled receptor kinases. Studies suggest that this phosphorylation promotes formation of alpha synuclein filaments, with hyperphosphorylation of Ser129 seen in Lewy bodies.
 Applications Tested/Suitable for anti-Snca antibody   

Western Blot (WB)*

 Application Notes for anti-Snca antibody    Western Blot: This item detects a band of approximately 15kDa in rat cortex lysate.
Western Blotting: Maximum Dilution: 1/1000; Application Note: For the detection of phosphoproteins, serine phosphatase inhibitors such as 10mM Sodium Fluoride should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background.
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NCBI/Uniprot data below describe general gene information for Snca. It may not necessarily be applicable to this product.
 NCBI GI #    9507125
 NCBI GeneID    29219
 NCBI Accession #    NP_062042.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019169.2 [Other Products]
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 UniProt Primary Accession #    P37377 [Other Products]
 UniProt Secondary Accession #    P37378; Q53YM9 [Other Products]
 UniProt Related Accession #    P37377 [Other Products]
 Molecular Weight    4,354 Da [Similar Products]
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 NCBI Official Full Name    alpha-synuclein
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    Snca [Similar Products]
 NCBI Protein Information    alpha-synuclein
 UniProt Protein Name    Alpha-synuclein
 Protein Family    Alpha-synuclein
 UniProt Gene Name    Snca [Similar Products]
 UniProt Entry Name    SYUA_RAT
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 NCBI Summary for Snca    may play a role in regulation of synaptic vesicle biogenesis and organization; may be involved in neurotransmission [RGD, Feb 2006]
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 UniProt Comments for Snca    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Cellular Component: Golgi apparatus; nuclear outer membrane; cytoplasmic vesicle membrane; mitochondrion; rough endoplasmic reticulum; intracellular membrane-bound organelle; cell; fibril; terminal button; inclusion body; cell cortex; cytosol; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; cytoskeleton; growth cone; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; ribosome; synapse; nerve terminal; nucleus

Molecular Function: identical protein binding; histone binding; zinc ion binding; kinesin binding; ferrous iron binding; magnesium ion binding; calcium ion binding; oxidoreductase activity; Hsp70 protein binding; phospholipase binding; enzyme binding; phospholipid binding; fatty acid binding; alpha-tubulin binding; protein domain specific binding; microtubule binding; caspase inhibitor activity; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; arachidonic acid binding; dynein binding; protein binding; copper ion binding; tau protein binding

Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; regulation of neurotransmitter secretion; positive regulation of endocytosis; response to lipopolysaccharide; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; dopamine metabolic process; calcium ion homeostasis; response to magnesium ion; regulation of neuron apoptosis; synapse organization and biogenesis; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of neuronal synaptic plasticity; regulation of long-term neuronal synaptic plasticity; synaptic transmission, dopaminergic; negative regulation of serotonin uptake; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; negative regulation of monooxygenase activity; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of synaptic transmission; negative regulation of histone acetylation; negative regulation of dopamine uptake; synaptic transmission; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; receptor internalization; phospholipid metabolic process; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; regulation of glutamate secretion; regulation of macrophage activation; negative regulation of microtubule polymerization; synaptic vesicle transport; response to cocaine; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential
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 Research Articles on Snca    1. It impairs maturation of oligodendrocyte progenitors thereby contributing to multiple system atrophy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Snca antibodyPathways associated with anti-Snca antibody
 Reference Product  PubMed Publications
 Park2 antibody  >945 publications with Snca and Park2
 Lrrk2 antibody  >138 publications with Snca and Lrrk2
 Mapt antibody  >83 publications with Snca and Mapt
 Park7 antibody  >53 publications with Snca and Park7
 Sncaip antibody  >33 publications with Snca and Sncaip
 Slc6a3 antibody  >25 publications with Snca and Slc6a3
 Stub1 antibody  >1 publications with Snca and Stub1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
Diseases associated with anti-Snca antibodyOrgans/Tissues associated with anti-Snca antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1175 publications with Snca and Nervous System Diseases
 Brain Diseases Antibodies  >1150 publications with Snca and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1136 publications with Snca and Neurodegenerative Diseases
 Movement Disorders Antibodies  >1014 publications with Snca and Movement Disorders
 Parkinsonian Disorders Antibodies  >939 publications with Snca and Parkinsonian Disorders
 Parkinson Disease Antibodies  >888 publications with Snca and Parkinson Disease
 Lewy Body Disease Antibodies  >282 publications with Snca and Lewy Body Disease
 Nerve Degeneration Antibodies  >168 publications with Snca and Nerve Degeneration
 Disease Models, Animal Antibodies  >151 publications with Snca and Disease Models, Animal
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >57 publications with Snca and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >803 publications with Snca and Brain
 Heart Antibodies  >10 publications with Snca and Heart
 Eye Antibodies  >10 publications with Snca and Eye
 Liver Antibodies  >7 publications with Snca and Liver
 Dorsal Root Ganglion Antibodies  >6 publications with Snca and Dorsal Root Ganglion
 Prostate Antibodies  >2 publications with Snca and Prostate
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