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anti-ALPL antibody :: Rabbit ALPL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524044
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALPL, Polyclonal Antibody

★Popular Item★
 Also Known As   

ALPL Polyclonal Antibody

 Product Synonym Names    HOPS, TNAP, APTNAP, TNSALP, AP-TNAP
 Product Gene Name   

anti-ALPL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146300
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.5mg/mL (lot specific)
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 Immunogen    Recombinant protein of human ALPL
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ALPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ALPL antibody

   There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
 Product Categories/Family for anti-ALPL antibody    Stem cells; Cell biology
 Applications Tested/Suitable for anti-ALPL antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-ALPL antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-ALPL antibody    Immunohistochemistry of paraffin-embedded Human tonsil tissue using ALPL Polyclonal Antibody at dilution 1:25
anti-ALPL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ALPL. It may not necessarily be applicable to this product.
 NCBI GI #    294660772
 NCBI GeneID    249
 NCBI Accession #    NP_001170991.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001177520.1 [Other Products]
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 UniProt Secondary Accession #    O75090; Q2TAI7; Q59EJ7; Q5BKZ5; Q5VTG5; Q6NZI8; Q8WU32; A1A4E7; B2RMP8; B7Z387; B7Z4Y6 [Other Products]
 UniProt Related Accession #    P05186 [Other Products]
 Molecular Weight    51,045 Da
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 NCBI Official Full Name    alkaline phosphatase, tissue-nonspecific isozyme isoform 3
 NCBI Official Synonym Full Names    alkaline phosphatase, liver/bone/kidney
 NCBI Official Symbol    ALPL [Similar Products]
 NCBI Official Synonym Symbols   
HOPS; TNAP; APTNAP; TNSALP; AP-TNAP
[Similar Products]
 NCBI Protein Information    alkaline phosphatase, tissue-nonspecific isozyme; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphomonoesterase; glycerophosphatase; liver/bone/kidney-type alkaline phosphatase; tissue-nonspecific ALP
 UniProt Protein Name    Alkaline phosphatase, tissue-nonspecific isozyme
 UniProt Synonym Protein Names   
Alkaline phosphatase liver/bone/kidney isozyme
 Protein Family    Alkaline phosphatase
 UniProt Gene Name    ALPL [Similar Products]
 UniProt Synonym Gene Names    AP-TNAP; TNSALP [Similar Products]
 UniProt Entry Name    PPBT_HUMAN
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 NCBI Summary for ALPL    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
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 UniProt Comments for ALPL    ALPL: This isozyme may play a role in skeletal mineralization. Defects in ALPL are a cause of hypophosphatasia (HOPS). HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC). Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI). Belongs to the alkaline phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Phosphatase (non-protein); Membrane protein, GPI anchor; Cofactor and Vitamin Metabolism - folate biosynthesis; Motility/polarity/chemotaxis; EC 3.1.3.1

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: extracellular matrix; extracellular space; membrane; plasma membrane; integral to membrane

Molecular Function: pyrophosphatase activity; protein binding; alkaline phosphatase activity; metal ion binding

Biological Process: osteoblast differentiation; response to antibiotic; response to vitamin D; dephosphorylation; response to glucocorticoid stimulus; reproductive developmental process; response to lipopolysaccharide; skeletal development; endochondral ossification

Disease: Hypophosphatasia, Infantile; Hypophosphatasia, Adult; Hypophosphatasia, Childhood
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 Research Articles on ALPL    1. DNMT inhibitors facilitate the Pi-induced development of vascular calcification via the upregulation of the ALP expression along with a reduction in the DNA methylation level of the ALP promoter region.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ALPL antibodyDiseases associated with anti-ALPL antibody
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >12 publications with ALPL and Kidney Diseases
 Cardiovascular Diseases Antibodies  >12 publications with ALPL and Cardiovascular Diseases
 Seizures Antibodies  >11 publications with ALPL and Seizures
 Pain Antibodies  >9 publications with ALPL and Pain
 Inflammation Antibodies  >8 publications with ALPL and Inflammation
 Calcinosis Antibodies  >6 publications with ALPL and Calcinosis
 Liver Diseases Antibodies  >5 publications with ALPL and Liver Diseases
 Necrosis Antibodies  >4 publications with ALPL and Necrosis
 Hypertension Antibodies  >4 publications with ALPL and Hypertension
 Hypertrophy Antibodies  >4 publications with ALPL and Hypertrophy
Organs/Tissues associated with anti-ALPL antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >174 publications with ALPL and Bone
 Blood Antibodies  >55 publications with ALPL and Blood
 Kidney Antibodies  >42 publications with ALPL and Kidney
 Liver Antibodies  >40 publications with ALPL and Liver
 Connective Tissue Antibodies  >39 publications with ALPL and Connective Tissue
 Mouth Antibodies  >15 publications with ALPL and Mouth
 Adipose Tissue Antibodies  >15 publications with ALPL and Adipose Tissue
 Brain Antibodies  >14 publications with ALPL and Brain
 Skin Antibodies  >10 publications with ALPL and Skin
 Embryonic Tissue Antibodies  >7 publications with ALPL and Embryonic Tissue
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