NP_068745.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,241 Da
NCBI Official Full Name
homeobox protein aristaless-like 4
NCBI Official Synonym Full Names
ALX homeobox 4
NCBI Official Synonym Symbols
NCBI Protein Information
homeobox protein aristaless-like 4
UniProt Protein Name
Homeobox protein aristaless-like 4
UniProt Synonym Gene Names
NCBI Summary for ALX4
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, cognitive disability, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009]
UniProt Comments for ALX4
Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
Research Articles on ALX4
Precautions
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Products associated with anti-ALX4 antibody
Diseases associated with anti-ALX4 antibody
Organs/Tissues associated with anti-ALX4 antibody
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