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anti-AMHR2 antibody :: Rabbit AMHR2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9200710
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AMHR2, Polyclonal Antibody

★Popular Item★
 Also Known As   

AMHR2 Antibody (C-term)

 Product Synonym Names    Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII; AMHR2; AMHR; MISR2
 Product Gene Name   

anti-AMHR2 antibody

[Similar Products]
 Antibody/Peptide Pairs    AMHR2 peptide (MBS9226599) is used for blocking the activity of AMHR2 antibody (MBS9200710)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    374-402
 OMIM    261550
 3D Structure    ModBase 3D Structure for Q16671
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Mouse, Rat)
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 Specificity    This AMHR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-402 amino acids from the C-terminal region of human AMHR2.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-AMHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AMHR2 antibody

   The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
 Product Categories/Family for anti-AMHR2 antibody    Signal Transduction
 Applications Tested/Suitable for anti-AMHR2 antibody   

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)

 Application Notes for anti-AMHR2 antibody    WB~~1:1000
FC~~1:10~50
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 Western Blot (WB) of anti-AMHR2 antibody    Western blot analysis of AMHR2 Antibody (C-term) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.
anti-AMHR2 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-AMHR2 antibody    Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-AMHR2 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Western Blot (WB) of anti-AMHR2 antibody    Western blot analysis of AMHR2 Antibody (C-term) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.
anti-AMHR2 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-AMHR2 antibody    Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-AMHR2 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for AMHR2. It may not necessarily be applicable to this product.
 NCBI GI #    257743467
 NCBI GeneID    269
 NCBI Accession #    NP_001158162.1 [Other Products]
 NCBI Related Accession #    NP_001158163.1; NP_065434.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001164690.1 [Other Products]
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 UniProt Primary Accession #    Q16671 [Other Products]
 UniProt Secondary Accession #    Q13762; Q647K2; A0AVE1; B9EGB7; E9PGD2; F8W1D2 [Other Products]
 UniProt Related Accession #    Q16671 [Other Products]
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 NCBI Official Full Name    anti-Muellerian hormone type-2 receptor isoform 2
 NCBI Official Synonym Full Names    anti-Mullerian hormone receptor, type II
 NCBI Official Symbol    AMHR2 [Similar Products]
 NCBI Official Synonym Symbols   
AMHR; MRII; MISR2; MISRII
[Similar Products]
 NCBI Protein Information    anti-Muellerian hormone type-2 receptor
 UniProt Protein Name    Anti-Muellerian hormone type-2 receptor
 UniProt Synonym Protein Names   
Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII
 Protein Family    Anti-Muellerian hormone type-2 receptor
 UniProt Gene Name    AMHR2 [Similar Products]
 UniProt Synonym Gene Names    AMHR; MISR2; AMH type II receptor; MISRII; MRII [Similar Products]
 UniProt Entry Name    AMHR2_HUMAN
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 NCBI Summary for AMHR2    This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]
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 UniProt Comments for AMHR2    MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; hormone binding; transforming growth factor beta receptor activity, type II; metal ion binding; receptor activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: Mullerian duct regression; transforming growth factor beta receptor signaling pathway; signal transduction; protein amino acid phosphorylation; sex differentiation

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii
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Product References and Citations for anti-AMHR2 antibody

   Picard, J.Y., et al., J. Soc. Biol. 196(3):217-221 (2002).
Teixeira, J., et al., Endocr. Rev. 22(5):657-674 (2001).
Imbeaud, S., et al., Nat. Genet. 11(4):382-388 (1995).
Visser, J.A., et al., Biochem. Biophys. Res. Commun. 215(3):1029-1036 (1995).
Sinisi, A.A., et al., J. Endocrinol. Invest. 26 (3 Suppl), 23-28 (2003).
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 Research Articles on AMHR2    1. The possible involvement of AMHRII -482 A>G polymorphism on the malfunction of follicular development in Japanese women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AMHR2 antibodyDiseases associated with anti-AMHR2 antibody
 Reference Product  PubMed Publications
 AMH antibody  >38 publications with AMHR2 and AMH
 ACVR1 antibody  >2 publications with AMHR2 and ACVR1
 BMP6 antibody  >1 publications with AMHR2 and BMP6
 BMP4 antibody  >1 publications with AMHR2 and BMP4
 SMAD1 antibody  >1 publications with AMHR2 and SMAD1
 SMAD5 antibody  >1 publications with AMHR2 and SMAD5
 SMAD9 antibody  >1 publications with AMHR2 and SMAD9
 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >29 publications with AMHR2 and Female Urogenital Diseases
 Infertility, Female Antibodies  >12 publications with AMHR2 and Infertility, Female
 Infertility, Male Antibodies  >6 publications with AMHR2 and Infertility, Male
 Persistent Mullerian duct syndrome Antibodies  >6 publications with AMHR2 and Persistent Mullerian duct syndrome
 Testicular Diseases Antibodies  >5 publications with AMHR2 and Testicular Diseases
 Carcinoma Antibodies  >5 publications with AMHR2 and Carcinoma
 Hyperplasia Antibodies  >4 publications with AMHR2 and Hyperplasia
 Inflammation Antibodies  >2 publications with AMHR2 and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with AMHR2 and Cardiovascular Diseases
 Precancerous Conditions Antibodies  >1 publications with AMHR2 and Precancerous Conditions
Organs/Tissues associated with anti-AMHR2 antibody
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >34 publications with AMHR2 and Ovary
 Testis Antibodies  >17 publications with AMHR2 and Testis
 Muscle Antibodies  >8 publications with AMHR2 and Muscle
 Placenta Antibodies  >4 publications with AMHR2 and Placenta
 Heart Antibodies  >2 publications with AMHR2 and Heart
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