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anti-GRIA1 antibody :: Goat AMPA1/GLUR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422615
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AMPA1/GLUR1 (GRIA1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-AMPA1/GLUR1 (aa264-277) Antibody

 Product Synonym Names    Goat Anti-AMPA1 / GLUR1 Antibody; GRIA1; glutamate receptor, ionotropic, AMPA 1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; MGC133252; AMPA 1; AMPA-selective glutamate receptor 1; gluR-1; gluR-A; gluR-K1; glutamate receptor 1; GRIA1 antibody; glutamate receptor; ionotropic; AMPA 1 antibody; GLUH1 antibody; GLUR1 antibody; GLURA antibody; GluA1 antibody; HBGR1 antibody; MGC133252 antibody; AMPA 1 antibody; gluR-1 antibody; gluR-A antibody; gluR-K1 antibody; glutamate receptor 1 antibody; AMPA1 / GLUR1 (aa264-277)
 Product Gene Name   

anti-GRIA1 antibody

[Similar Products]
 Product Synonym Gene Name    AMPA1; GLUR1 [Similar Products]
 Antibody/Peptide Pairs    AMPA1 / GLUR1 peptide (MBS427617) is used for blocking the activity of AMPA1/GLUR1 antibody (MBS422615)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KIMQQWKNSD ARD
 OMIM    138248
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KIMQQWKNSDARD, from the internal region of the protein sequence according to NP_000818.2; NP_001107655.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_000818.2; NP_001107655.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GRIA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GRIA1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GRIA1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 100kDa band observed in Human, Mouse and Rat Brain (Cerebellum) lysates (calculated MW of 102kDa according to NP_000818.2). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-GRIA1 antibody    (0.1ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GRIA1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GRIA1. It may not necessarily be applicable to this product.
 NCBI GI #    167001419
 NCBI GeneID    2890
 NCBI Accession #    NP_000818.2 [Other Products]
 NCBI Related Accession #    NP_001107655.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000827.3 [Other Products]
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 UniProt Secondary Accession #    Q2NKM6; B7Z2S0; B7Z2W8; B7Z3F6; B7Z9G9; D3DQI4; E7ESV8 [Other Products]
 UniProt Related Accession #    P42261 [Other Products]
 Molecular Weight    102,864 Da
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 NCBI Official Full Name    glutamate receptor 1 isoform 1
 NCBI Official Synonym Full Names    glutamate ionotropic receptor AMPA type subunit 1
 NCBI Official Symbol    GRIA1 [Similar Products]
 NCBI Official Synonym Symbols   
GLUH1; GLUR1; GLURA; GluA1; HBGR1
[Similar Products]
 NCBI Protein Information    glutamate receptor 1
 UniProt Protein Name    Glutamate receptor 1
 UniProt Synonym Protein Names   
AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1
 UniProt Gene Name    GRIA1 [Similar Products]
 UniProt Synonym Gene Names    GLUH1; GLUR1; GluR-1; GluA1 [Similar Products]
 UniProt Entry Name    GRIA1_HUMAN
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 NCBI Summary for GRIA1    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRIA1    GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, calcium

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cell junction; cell soma; cell surface; dendrite; dendritic spine; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi membrane; plasma membrane; postsynaptic density; postsynaptic membrane; recycling endosome; synaptic vesicle

Molecular Function: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; excitatory extracellular ligand-gated ion channel activity; extracellular-glutamate-gated ion channel activity; glutamate receptor activity; PDZ domain binding; protein binding

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; ionotropic glutamate receptor signaling pathway; long-term memory; receptor internalization; signal transduction; synaptic transmission
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 Research Articles on GRIA1    1. The level of phosphorylated GluA1 at S831 and S845, two major sites implicated in AMPAR regulation, is almost negligible. Results impel us to reconsider the mechanisms underlying synaptic plasticity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GRIA1 antibodyPathways associated with anti-GRIA1 antibody
 Reference Product  PubMed Publications
 GRIA2 antibody  >17 publications with GRIA1 and GRIA2
 BDNF antibody  >6 publications with GRIA1 and BDNF
 DLG4 antibody  >1 publications with GRIA1 and DLG4
 Products by Pathway  Pathway Diagram
 Activation Of AMPA Receptors Pathway antibodies  Activation Of AMPA Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
Diseases associated with anti-GRIA1 antibodyOrgans/Tissues associated with anti-GRIA1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with GRIA1 and Nervous System Diseases
 Brain Diseases Antibodies  >6 publications with GRIA1 and Brain Diseases
 Pain Antibodies  >6 publications with GRIA1 and Pain
 Depressive Disorder Antibodies  >4 publications with GRIA1 and Depressive Disorder
 Memory Disorders Antibodies  >3 publications with GRIA1 and Memory Disorders
 Anxiety Disorders Antibodies  >3 publications with GRIA1 and Anxiety Disorders
 Disease Models, Animal Antibodies  >3 publications with GRIA1 and Disease Models, Animal
 Hypertension Antibodies  >2 publications with GRIA1 and Hypertension
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with GRIA1 and Prenatal Exposure Delayed Effects
 Sexual Dysfunctions, Psychological Antibodies  >2 publications with GRIA1 and Sexual Dysfunctions, Psychological
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >48 publications with GRIA1 and Brain
 Blood Antibodies  >6 publications with GRIA1 and Blood
 Lung Antibodies  >2 publications with GRIA1 and Lung
 Muscle Antibodies  >1 publications with GRIA1 and Muscle
 Eye Antibodies  >1 publications with GRIA1 and Eye
 Embryonic Tissue Antibodies  >1 publications with GRIA1 and Embryonic Tissue
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