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anti-AMPD1 antibody :: Rabbit AMPD1 / MAD Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241698
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AMPD1 / MAD, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human AMPD1 / MAD

 Product Synonym Names    Anti-AMPD1 / MAD Antibody (aa500-550) IHC-plus; AMPD1; AMP deaminase isoform M; AMP deaminase 1; AMPD; Skeletal muscle AMPD; MAD; MADA; Myoadenylate deaminase; Human AMPD1; MAD
 Product Gene Name   

anti-AMPD1 antibody

[Similar Products]
 Product Synonym Gene Name    MAD [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615511
 3D Structure    ModBase 3D Structure for P23109
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bovine, Chimpanzee, Human, Monkey, Mouse, Rat, Zebrafish
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 Specificity    A portion of amino acids 500-550 of human AMPDA1
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.2% gelatin, 0.05% sodium azide.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human AMPD1.
 Immunogen Type    Synthetic peptide
 Immunogen    AMPD1 / MAD antibody was raised against synthetic peptide from human AMPD1.
 Antigen Modification    aa500-550
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-AMPD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AMPD1 antibody

   Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human.
 Applications Tested/Suitable for anti-AMPD1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-AMPD1 antibody    IHC-P (5 - 10 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-AMPD1 antibody    Anti-AMPD1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-AMPD1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-AMPD1 antibody    Western blot of AMPDA1 in rat skeletal muscle lysate in the 1) absence, 2) presence of immunizing peptide and 3) mouse?skeletal muscle using antibody at 0.5 ug/ml.
anti-AMPD1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for AMPD1. It may not necessarily be applicable to this product.
 NCBI GI #    289547500
 NCBI GeneID    270
 NCBI Accession #    NP_000027.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000036.2 [Other Products]
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 UniProt Primary Accession #    P23109 [Other Products]
 UniProt Secondary Accession #    Q5TF00; Q5TF02; A8K5N4; B2RAM1; F2Z3B3 [Other Products]
 UniProt Related Accession #    P23109 [Other Products]
 Molecular Weight    89,763 Da
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 NCBI Official Full Name    AMP deaminase 1 isoform 1
 NCBI Official Synonym Full Names    adenosine monophosphate deaminase 1
 NCBI Official Symbol    AMPD1 [Similar Products]
 NCBI Official Synonym Symbols   
MAD; MADA; MMDD
[Similar Products]
 NCBI Protein Information    AMP deaminase 1; AMPD; skeletal muscle AMPD; myoadenylate deaminase; adenosine monophosphate deaminase-1 (muscle); adenosine monophosphate deaminase 1 (isoform M)
 UniProt Protein Name    AMP deaminase 1
 UniProt Synonym Protein Names   
AMP deaminase isoform M; Myoadenylate deaminase
 Protein Family    AMP deaminase
 UniProt Gene Name    AMPD1 [Similar Products]
 UniProt Entry Name    AMPD1_HUMAN
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 NCBI Summary for AMPD1    Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
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 UniProt Comments for AMPD1    AMPD1: AMP deaminase plays a critical role in energy metabolism. Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type (AMPDDM). AMPDDM is a metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue. Belongs to the adenosine and AMP deaminases family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.4.6; Nucleotide Metabolism - purine; Hydrolase

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: cytosol

Molecular Function: metal ion binding; AMP deaminase activity; myosin heavy chain binding

Biological Process: response to organic substance; IMP salvage; nucleobase, nucleoside and nucleotide metabolic process; purine salvage; purine base metabolic process

Disease: Myopathy Due To Myoadenylate Deaminase Deficiency
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 Research Articles on AMPD1    1. Our other studies on the metabolic impact of AMPD1 C34T mutation revealed decrease in AMPD activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AMPD1 antibodyPathways associated with anti-AMPD1 antibody
 Reference Product  PubMed Publications
 ATIC antibody  >5 publications with AMPD1 and ATIC
 ITPA antibody  >4 publications with AMPD1 and ITPA
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Salvage Pathway antibodies  Purine Salvage Pathway Diagram
Diseases associated with anti-AMPD1 antibodyOrgans/Tissues associated with anti-AMPD1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >29 publications with AMPD1 and Cardiovascular Diseases
 Muscular Diseases Antibodies  >11 publications with AMPD1 and Muscular Diseases
 Muscle Weakness Antibodies  >7 publications with AMPD1 and Muscle Weakness
 Inflammation Antibodies  >4 publications with AMPD1 and Inflammation
 Necrosis Antibodies  >3 publications with AMPD1 and Necrosis
 Atherosclerosis Antibodies  >2 publications with AMPD1 and Atherosclerosis
 Anemia Antibodies  >2 publications with AMPD1 and Anemia
 Brain Diseases Antibodies  >2 publications with AMPD1 and Brain Diseases
 Asthma Antibodies  >1 publications with AMPD1 and Asthma
 Carcinoma, Hepatocellular Antibodies  >1 publications with AMPD1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >79 publications with AMPD1 and Muscle
 Heart Antibodies  >35 publications with AMPD1 and Heart
 Liver Antibodies  >6 publications with AMPD1 and Liver
 Embryonic Tissue Antibodies  >2 publications with AMPD1 and Embryonic Tissue
 Lung Antibodies  >2 publications with AMPD1 and Lung
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