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anti-AMPD1 antibody :: Goat AMPD1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421094 anti-AMPD1 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AMPD1, Polyclonal Antibody

 Also Known As   

Goat anti-AMPD1 Antibody

 Product Synonym Names    AMPD1; adenosine monophosphate deaminase 1 (isoform M); MAD; MADA; Adenosine monophosphate deaminase-1 (muscle); OTTHUMP00000059283; AMPD1 antibody; adenosine monophosphate deaminase 1 (isoform M) antibody; MAD antibody; MADA antibody; Adenosine monophosphate deaminase-1 (muscle) antibody; OTTHUMP00000059283 antibody
 Product Gene Name   

anti-AMPD1 antibody

[Similar Products]
 Antibody/Peptide Pairs    AMPD1 peptide (MBS425057) is used for blocking the activity of AMPD1 antibody (MBS421094)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    HMFSSKSPKP QE
 OMIM    102770
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-HMFSSKSPKPQE, from the internal region of the protein sequence according to NP_000027.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-AMPD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AMPD1 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-AMPD1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments in Human Muscle and Rat Muscle lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
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NCBI/Uniprot data below describe general gene information for AMPD1. It may not necessarily be applicable to this product.
 NCBI GI #    4557311
 NCBI GeneID    270
 NCBI Accession #    NP_000027.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000036.1 [Other Products]
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 UniProt Secondary Accession #    Q5TF00; Q5TF02; A8K5N4; B2RAM1; F2Z3B3 [Other Products]
 UniProt Related Accession #    P23109 [Other Products]
 Molecular Weight    89,763 Da
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 NCBI Official Full Name    adenosine monophosphate deaminase 1 (isoform M)
 NCBI Official Synonym Full Names    adenosine monophosphate deaminase 1
 NCBI Official Symbol    AMPD1 [Similar Products]
 NCBI Official Synonym Symbols   
MAD; MADA; MMDD
[Similar Products]
 NCBI Protein Information    AMP deaminase 1
 UniProt Protein Name    AMP deaminase 1
 UniProt Synonym Protein Names   
AMP deaminase isoform M; Myoadenylate deaminase
 Protein Family    AMP deaminase
 UniProt Gene Name    AMPD1 [Similar Products]
 UniProt Entry Name    AMPD1_HUMAN
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 NCBI Summary for AMPD1    Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
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 UniProt Comments for AMPD1    AMPD1: AMP deaminase plays a critical role in energy metabolism. Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type (AMPDDM). AMPDDM is a metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue. Belongs to the adenosine and AMP deaminases family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Hydrolase; EC 3.5.4.6

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: cytosol

Molecular Function: AMP deaminase activity; metal ion binding; myosin heavy chain binding

Biological Process: IMP salvage; purine salvage; response to organic substance

Disease: Myopathy Due To Myoadenylate Deaminase Deficiency
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 Research Articles on AMPD1    1. The best response to creatine in terms of physical performance was presented by AMPD1 CC genotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-AMPD1 antibodyDiseases associated with anti-AMPD1 antibody
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Salvage Pathway antibodies  Purine Salvage Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >30 publications with AMPD1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >29 publications with AMPD1 and Heart Diseases
 Nervous System Diseases Antibodies  >13 publications with AMPD1 and Nervous System Diseases
 Muscular Diseases Antibodies  >11 publications with AMPD1 and Muscular Diseases
 Muscle Weakness Antibodies  >7 publications with AMPD1 and Muscle Weakness
 Inflammation Antibodies  >6 publications with AMPD1 and Inflammation
 Atherosclerosis Antibodies  >3 publications with AMPD1 and Atherosclerosis
 Necrosis Antibodies  >3 publications with AMPD1 and Necrosis
 Weight Loss Antibodies  >2 publications with AMPD1 and Weight Loss
 Hypertrophy Antibodies  >2 publications with AMPD1 and Hypertrophy
Organs/Tissues associated with anti-AMPD1 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >83 publications with AMPD1 and Muscle
 Heart Antibodies  >40 publications with AMPD1 and Heart
 Liver Antibodies  >7 publications with AMPD1 and Liver
 Embryonic Tissue Antibodies  >2 publications with AMPD1 and Embryonic Tissue
 Lung Antibodies  >2 publications with AMPD1 and Lung
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