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anti-AMPH antibody :: Goat AMPH / Amphiphysin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242211
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AMPH / Amphiphysin, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human AMPH / Amphiphysin

 Product Synonym Names    Anti-AMPH / Amphiphysin Antibody (Internal) IHC-plus; AMPH1; Amphiphysin; Amphiphysin I; Human AMPH; Amphiphysin
 Product Gene Name   

anti-AMPH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600418
 3D Structure    ModBase 3D Structure for P49418
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat
Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity)
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 Specificity    Human AMPH / Amphiphysin. This antibody is expected to recognise both reported isoforms (NP_001626.1 and NP_647477.1).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-KRKDESRISKAE from an internal region of human AMPH / Amphiphysin (NP_001626.1; NP_647477.1).
 Immunogen Type    Synthetic peptide
 Immunogen    AMPH / Amphiphysin antibody was raised against synthetic peptide C-KRKDESRISKAE from an internal region of human AMPH / Amphiphysin (NP_001626.1; NP_647477.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit (100%); Xenopus (92%); Opossum, Chicken, Lizard (83%).
 Antigen Modification    Internal
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-AMPH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AMPH antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-AMPH antibody    ELISA (1:16000), IHC-P (2.5 ug/ml), WB (0.1 - 0.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-AMPH antibody    Anti-AMPH / Amphiphysin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-AMPH antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-AMPH antibody    Antibody (0.5 ug/ml) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-AMPH antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for AMPH. It may not necessarily be applicable to this product.
 NCBI GI #    4502081
 NCBI GeneID    273
 NCBI Accession #    NP_001626.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001635.3 [Other Products]
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 UniProt Primary Accession #    P49418 [Other Products]
 UniProt Secondary Accession #    O43538; Q75MJ8; Q75MK5; Q75MM3; Q8N4G0; A4D1X8; A4D1X9 [Other Products]
 UniProt Related Accession #    P49418 [Other Products]
 Molecular Weight    71,929 Da
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 NCBI Official Full Name    amphiphysin isoform 1
 NCBI Official Synonym Full Names    amphiphysin
 NCBI Official Symbol    AMPH [Similar Products]
 NCBI Official Synonym Symbols   
AMPH1
[Similar Products]
 NCBI Protein Information    amphiphysin; amphiphysin I; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen)
 UniProt Protein Name    Amphiphysin
 Protein Family    Amphiphysin
 UniProt Gene Name    AMPH [Similar Products]
 UniProt Synonym Gene Names    AMPH1 [Similar Products]
 UniProt Entry Name    AMPH_HUMAN
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 NCBI Summary for AMPH    This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010]
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 UniProt Comments for AMPH    amphiphysin: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 7p14-p13

Cellular Component: synaptic vesicle; synaptic vesicle membrane; cell junction; actin cytoskeleton

Molecular Function: protein binding; phospholipid binding

Biological Process: synaptic transmission; synaptic vesicle endocytosis; endocytosis; learning
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 Research Articles on AMPH    1. AMPH1 protein level is reduced in transgenic mouse brain proteins. in the brainstem of nontransgenic and terminally ill JNPL3 transgenic mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AMPH antibodyPathways associated with anti-AMPH antibody
 Reference Product  PubMed Publications
 CDK5 antibody  >2 publications with AMPH and CDK5
 EGFR antibody  >1 publications with AMPH and EGFR
 SH3GL2 antibody  >1 publications with AMPH and SH3GL2
 Products by Pathway  Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Internalization Of ErbB1 Pathway antibodies  Internalization Of ErbB1 Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
Diseases associated with anti-AMPH antibodyOrgans/Tissues associated with anti-AMPH antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >79 publications with AMPH and Disease Models, Animal
 Brain Diseases Antibodies  >38 publications with AMPH and Brain Diseases
 Immune System Diseases Antibodies  >31 publications with AMPH and Immune System Diseases
 Pregnancy Complications Antibodies  >20 publications with AMPH and Pregnancy Complications
 Inflammation Antibodies  >19 publications with AMPH and Inflammation
 Prenatal Injuries Antibodies  >19 publications with AMPH and Prenatal Injuries
 Prenatal Exposure Delayed Effects Antibodies  >19 publications with AMPH and Prenatal Exposure Delayed Effects
 Cardiovascular Diseases Antibodies  >16 publications with AMPH and Cardiovascular Diseases
 Poisoning Antibodies  >15 publications with AMPH and Poisoning
 Nerve Degeneration Antibodies  >14 publications with AMPH and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >657 publications with AMPH and Brain
 Lung Antibodies  >35 publications with AMPH and Lung
 Kidney Antibodies  >18 publications with AMPH and Kidney
 Heart Antibodies  >16 publications with AMPH and Heart
 Bone Antibodies  >13 publications with AMPH and Bone
 Eye Antibodies  >5 publications with AMPH and Eye
 Testis Antibodies  >5 publications with AMPH and Testis
 Embryonic Tissue Antibodies  >4 publications with AMPH and Embryonic Tissue
 Pineal Gland Antibodies  >3 publications with AMPH and Pineal Gland
 Pituitary Gland Antibodies  >2 publications with AMPH and Pituitary Gland
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