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anti-AMPK gamma 1 antibody :: Rabbit AMPK gamma 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS852386
Testing Data
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AMPK gamma 1, Polyclonal Antibody

 Also Known As   

AMPK gamma 1 Antibody

 Product Gene Name   

anti-AMPK gamma 1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602742
 3D Structure    ModBase 3D Structure for P54619
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    Lyophilized anti-AMPK gamma 1 antibody purified by protein A column containing 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal AMPK gamma 1(1) antibody was raised against a 15 amino acid peptide at the intermediate residues of human AMPK gamma 1 protein.
 Reactivity Note    Not yet tested in other species.
 Pathway    5'-AMP-activated protein kinase subunit gamma-1
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 Other Notes    Small volumes of anti-AMPK gamma 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-AMPK gamma 1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-AMPK gamma 1 antibody   

Western Blot (WB)

 Application Notes for anti-AMPK gamma 1 antibody    Peptide ELISA titer: 1:80,000
Western blot analysis: 1:200-1,000
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-AMPK gamma 1 antibody    anti-AMPK gamma 1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for AMPK gamma 1. It may not necessarily be applicable to this product.
 NCBI GI #    332000015
 NCBI GeneID    5571
 NCBI Accession #    NP_001193638.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206709.1 [Other Products]
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 UniProt Primary Accession #    P54619 [Other Products]
 UniProt Secondary Accession #    Q8N7V9; B4DDT7 [Other Products]
 UniProt Related Accession #    P54619 [Other Products]
 Molecular Weight    38,533 Da
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 NCBI Official Full Name    5'-AMP-activated protein kinase subunit gamma-1 isoform 3
 NCBI Official Synonym Full Names    protein kinase, AMP-activated, gamma 1 non-catalytic subunit
 NCBI Official Symbol    PRKAG1 [Similar Products]
 NCBI Official Synonym Symbols   
AMPKG
[Similar Products]
 NCBI Protein Information    5'-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK gamma-1 chain; 5'-AMP-activated protein kinase, gamma-1 subunit
 UniProt Protein Name    5'-AMP-activated protein kinase subunit gamma-1
 UniProt Gene Name    PRKAG1 [Similar Products]
 UniProt Synonym Gene Names    AMPK gamma1; AMPK subunit gamma-1; AMPKg [Similar Products]
 UniProt Entry Name    AAKG1_HUMAN
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 NCBI Summary for AMPK gamma 1    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AMPK gamma 1    AMPKG1: a non-catalytic subunit of AMPK, a highly conserved kinase of the CAMKL family. The holoenzyme consists of a catalytic subunit (alpha) and two regulatory subunits (beta, gamma). Each subunit exists as multiple genetic isoforms giving rise to 12 different possible combinations of holoenzyme. Plays a key role in regulation of energy homeostasis. Activated by an elevated AMP-ATP ratio due to environmental stress, such as heat shock, hypoxia and ischemia. AMPK phosphorylates and regulates many metabolic enzymes.

Protein type: Autophagy; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 12q12-q14

Cellular Component: membrane; cytosol; nucleus; AMP-activated protein kinase complex

Molecular Function: AMP-activated protein kinase activity; protein binding; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase regulator activity; ADP binding; protein kinase binding; ATP binding; protein kinase activity; AMP binding

Biological Process: mitochondrion organization and biogenesis; protein heterooligomerization; positive regulation of protein kinase activity; organelle organization and biogenesis; regulation of glycolysis; insulin receptor signaling pathway; spermatogenesis; signal transduction; cell cycle arrest; protein amino acid phosphorylation; fatty acid biosynthetic process
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Product References and Citations for anti-AMPK gamma 1 antibody

   (1) Beebe,S.J., Oyen,O., Sandberg,M. et,al. Molecular cloning of a tissue-specific protein kinase(Cgamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. Mol Endocrinol. 1990; 4(3):465-75.
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 Research Articles on AMPK gamma 1    1. Electrogenic phosphate transport in sodium/phosphate cotransporter NaPi-IIa-expressing Xenopus oocytes is markedly decreased by the coexpression of constitutively active AMPKgammaR70Q, but not of AMPK(alphaK45R).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AMPK gamma 1 antibodyPathways associated with anti-AMPK gamma 1 antibody
 Reference Product  PubMed Publications
 PRKAA1 antibody  >18 publications with AMPK gamma 1 and PRKAA1
 PRKAA2 antibody  >15 publications with AMPK gamma 1 and PRKAA2
 PRKAB1 antibody  >15 publications with AMPK gamma 1 and PRKAB1
 PRKAB2 antibody  >13 publications with AMPK gamma 1 and PRKAB2
 PRKAG2 antibody  >7 publications with AMPK gamma 1 and PRKAG2
 STK11 antibody  >2 publications with AMPK gamma 1 and STK11
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway antibodies  Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
Diseases associated with anti-AMPK gamma 1 antibodyOrgans/Tissues associated with anti-AMPK gamma 1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2 publications with AMPK gamma 1 and Cardiovascular Diseases
 Anemia Antibodies  >1 publications with AMPK gamma 1 and Anemia
 Carcinoma Antibodies  >1 publications with AMPK gamma 1 and Carcinoma
 Hypertrophy Antibodies  >1 publications with AMPK gamma 1 and Hypertrophy
 Nervous System Diseases Antibodies  >1 publications with AMPK gamma 1 and Nervous System Diseases
 Hyperplasia Antibodies  >1 publications with AMPK gamma 1 and Hyperplasia
 Fatty Liver Antibodies  >1 publications with AMPK gamma 1 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >12 publications with AMPK gamma 1 and Muscle
 Liver Antibodies  >9 publications with AMPK gamma 1 and Liver
 Heart Antibodies  >5 publications with AMPK gamma 1 and Heart
 Blood Antibodies  >3 publications with AMPK gamma 1 and Blood
 Lung Antibodies  >3 publications with AMPK gamma 1 and Lung
 Testis Antibodies  >3 publications with AMPK gamma 1 and Testis
 Ovary Antibodies  >2 publications with AMPK gamma 1 and Ovary
 Brain Antibodies  >2 publications with AMPK gamma 1 and Brain
 Thymus Antibodies  >1 publications with AMPK gamma 1 and Thymus
 Adrenal Gland Antibodies  >1 publications with AMPK gamma 1 and Adrenal Gland
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