AAH05217.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,252 Da
NCBI Official Full Name
ANAPC10 protein
NCBI Official Synonym Full Names
anaphase promoting complex subunit 10
NCBI Official Synonym Symbols
NCBI Protein Information
anaphase-promoting complex subunit 10; cyclosome subunit 10
UniProt Protein Name
Anaphase-promoting complex subunit 10
UniProt Synonym Protein Names
Cyclosome subunit 10
UniProt Synonym Gene Names
UniProt Entry Name
APC10_HUMAN
NCBI Summary for ANAPC10
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
UniProt Comments for ANAPC10
APC10: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC10 family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4q31
Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle
Research Articles on ANAPC10
Precautions
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Products associated with anti-ANAPC10 antibody
Pathways associated with anti-ANAPC10 antibody
Diseases associated with anti-ANAPC10 antibody
Organs/Tissues associated with anti-ANAPC10 antibody
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