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anti-ANAPC2 antibody :: Rabbit ANAPC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS853113
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ANAPC2, Polyclonal Antibody

 Also Known As   

ANAPC2 Antibody

 Product Gene Name   

anti-ANAPC2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606946
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
Predicted: Mouse, Rat
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 Form/Format    Purified by protein affinity column containing 1% BSA and 0.02% NaN3
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-ANAPC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ANAPC2 antibody

   Rabbit polyclonal ANAPC2 (1) antibody was raised against a recombinate human ANAPC2 protein 604-820aa (BC032503).
 Product Categories/Family for anti-ANAPC2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-ANAPC2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ANAPC2 antibody    ELISA: 1:20,000-1:80,000
WB: 1:1,000-1:2,000
IHC: 1:100-1:500
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 Testing Data of anti-ANAPC2 antibody    anti-ANAPC2 antibody Testing Data image
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 Testing Data of anti-ANAPC2 antibody    anti-ANAPC2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ANAPC2. It may not necessarily be applicable to this product.
 NCBI GI #    21595797
 NCBI GeneID    29882
 NCBI Accession #    BC032503 [Other Products]
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 UniProt Secondary Accession #    Q5VSG1; Q96DG5; Q96GG4; Q9P2E1 [Other Products]
 UniProt Related Accession #    Q9UJX6 [Other Products]
 Molecular Weight    93,469 Da
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 NCBI Official Full Name    Homo sapiens anaphase promoting complex subunit 2, mRNA
 NCBI Official Synonym Full Names    anaphase promoting complex subunit 2
 NCBI Official Symbol    ANAPC2 [Similar Products]
 NCBI Official Synonym Symbols   
APC2
[Similar Products]
 NCBI Protein Information    anaphase-promoting complex subunit 2
 UniProt Protein Name    Anaphase-promoting complex subunit 2
 UniProt Synonym Protein Names   
Cyclosome subunit 2
 Protein Family    Anaphase-promoting complex
 UniProt Gene Name    ANAPC2 [Similar Products]
 UniProt Synonym Gene Names    APC2; KIAA1406; APC2 [Similar Products]
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 NCBI Summary for ANAPC2    A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANAPC2    Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
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Product References and Citations for anti-ANAPC2 antibody

   (1) Jin, L., Williamson, A., Banerjee, S., et al. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 133 (4), 653-665 (2008).
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 Research Articles on ANAPC2    1. The authors showed, in vitro, a direct interaction between Orf virus anaphase promoting complex regulator and APC2 and its interference with interactions between APC11 and APC2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANAPC2 antibodyPathways associated with anti-ANAPC2 antibody
 Reference Product  PubMed Publications
 ANAPC1 antibody  >8 publications with ANAPC2 and ANAPC1
 CDC20 antibody  >8 publications with ANAPC2 and CDC20
 CDC23 antibody  >7 publications with ANAPC2 and CDC23
 CDC16 antibody  >6 publications with ANAPC2 and CDC16
 PTTG1 antibody  >6 publications with ANAPC2 and PTTG1
 CDC27 antibody  >6 publications with ANAPC2 and CDC27
 ANAPC5 antibody  >4 publications with ANAPC2 and ANAPC5
 CCNB1 antibody  >2 publications with ANAPC2 and CCNB1
 Products by Pathway  Pathway Diagram
 APC-Cdc20 Mediated Degradation Of Nek2A Pathway antibodies  APC-Cdc20 Mediated Degradation Of Nek2A Pathway Diagram
 APC/C Complex Pathway antibodies  APC/C Complex Pathway Diagram
 APC/C Complex Pathway antibodies  APC/C Complex Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
Diseases associated with anti-ANAPC2 antibodyOrgans/Tissues associated with anti-ANAPC2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with ANAPC2 and Nervous System Diseases
 Kidney Diseases Antibodies  >2 publications with ANAPC2 and Kidney Diseases
 Memory Disorders Antibodies  >1 publications with ANAPC2 and Memory Disorders
 Adenocarcinoma Antibodies  >1 publications with ANAPC2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >1 publications with ANAPC2 and Neoplasms, Experimental
 Uterine Neoplasms Antibodies  >1 publications with ANAPC2 and Uterine Neoplasms
 Urologic Neoplasms Antibodies  >1 publications with ANAPC2 and Urologic Neoplasms
 Kidney Neoplasms Antibodies  >1 publications with ANAPC2 and Kidney Neoplasms
 Learning Disorders Antibodies  >1 publications with ANAPC2 and Learning Disorders
 Uterine Cervical Neoplasms Antibodies  >1 publications with ANAPC2 and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with ANAPC2 and Kidney
 Liver Antibodies  >2 publications with ANAPC2 and Liver
 Ovary Antibodies  >1 publications with ANAPC2 and Ovary
 Muscle Antibodies  >1 publications with ANAPC2 and Muscle
 Pancreas Antibodies  >1 publications with ANAPC2 and Pancreas
 Eye Antibodies  >1 publications with ANAPC2 and Eye
 Skin Antibodies  >1 publications with ANAPC2 and Skin
 Blood Antibodies  >1 publications with ANAPC2 and Blood
 Embryonic Tissue Antibodies  >1 publications with ANAPC2 and Embryonic Tissue
 Nerve Antibodies  >1 publications with ANAPC2 and Nerve
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