NP_037499.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
anaphase-promoting complex subunit 4 isoform 2
NCBI Official Synonym Full Names
anaphase promoting complex subunit 4
NCBI Official Synonym Symbols
NCBI Protein Information
anaphase-promoting complex subunit 4
UniProt Protein Name
Anaphase-promoting complex subunit 4
UniProt Synonym Protein Names
Cyclosome subunit 4
UniProt Synonym Gene Names
UniProt Entry Name
APC4_HUMAN
NCBI Summary for ANAPC4
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Comments for ANAPC4
APC4: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC4 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component: nucleoplasm; anaphase-promoting complex; nucleus; cytosol
Molecular Function: protein binding; ubiquitin-protein ligase activity; protein phosphatase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle
Product References and Citations for anti-ANAPC4 antibody
Wasch, R., et al. Oncogene 29(1):1-10(2010) Jin, L., et al. Cell 133(4):653-665(2008) Nature 447(7145):661-678(2007) Dube, P., et al. Mol. Cell 20(6):867-879(2005) Listovsky, T., et al. EMBO J. 23(7):1619-1626(2004)
Research Articles on ANAPC4
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Products associated with anti-ANAPC4 antibody
Pathways associated with anti-ANAPC4 antibody
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