NP_055310.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,637 Da
NCBI Official Full Name
angiopoietin-related protein 3 preproprotein
NCBI Official Synonym Full Names
angiopoietin like 3
NCBI Protein Information
angiopoietin-related protein 3
UniProt Protein Name
Angiopoietin-related protein 3
UniProt Synonym Protein Names
Angiopoietin-5; ANG-5
UniProt Synonym Gene Names
UniProt Entry Name
ANGL3_HUMAN
NCBI Summary for ANGPTL3
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]
UniProt Comments for ANGPTL3
ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Cell adhesion; Secreted; Inhibitor
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: cell surface; early endosome; extracellular space; Golgi apparatus; lamellipodium
Molecular Function: enzyme inhibitor activity; growth factor activity; heparin binding; integrin binding; phospholipase inhibitor activity
Biological Process: acylglycerol homeostasis; angiogenesis; artery morphogenesis; cell-matrix adhesion; cholesterol homeostasis; cholesterol metabolic process; fatty acid metabolic process; glycerol metabolic process; integrin-mediated signaling pathway; lipid homeostasis; negative regulation of lipoprotein lipase activity; phospholipid catabolic process; phospholipid homeostasis; phospholipid metabolic process; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of lipid catabolic process; response to hormone stimulus; sequestering of lipid; signal transduction
Disease: Hypobetalipoproteinemia, Familial, 2
Research Articles on ANGPTL3
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Products associated with anti-ANGPTL3 antibody
Pathways associated with anti-ANGPTL3 antibody
Diseases associated with anti-ANGPTL3 antibody
Organs/Tissues associated with anti-ANGPTL3 antibody
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