BC023647
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,853 Da
NCBI Official Full Name
Homo sapiens angiopoietin-like 4, mRNA
NCBI Official Synonym Full Names
angiopoietin like 4
NCBI Official Synonym Symbols
NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158 [Similar Products]
NCBI Protein Information
angiopoietin-related protein 4
UniProt Protein Name
Angiopoietin-related protein 4
UniProt Synonym Protein Names
Angiopoietin-like protein 4; Hepatic fibrinogen/angiopoietin-related protein; HFARP
UniProt Synonym Gene Names
NCBI Summary for ANGPTL4
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
UniProt Comments for ANGPTL4
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation ().
Product References and Citations for anti-ANGPTL4 antibody
(1) Lei, X., Shi, F., Basu, D., et al. Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity. J. Biol. Chem. 286 (18), 15747-15756 (2011).
Research Articles on ANGPTL4
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Products associated with anti-ANGPTL4 antibody
Pathways associated with anti-ANGPTL4 antibody
Diseases associated with anti-ANGPTL4 antibody
Organs/Tissues associated with anti-ANGPTL4 antibody
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