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anti-ANLN antibody :: Goat ANILLIN/Scraps Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421177
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ANILLIN/Scraps (ANLN), Polyclonal Antibody

 Also Known As   

Goat anti-ANILLIN/Scraps (C Terminus) Antibody

 Product Synonym Names    Goat Anti-ANILLIN / Scraps (internal) Antibody; ANLN; Scraps; ANILLIN; anillin, actin binding protein (scraps homolog, Drosophila); anillin (Drosophila Scraps homolog), actin binding protein; anillin, actin binding protein; DKFZp779A055; scra; ANLN antibody; Scraps antibody; ANILLIN antibody; anillin; actin binding protein (scraps homolog; Drosophila) antibody; anillin (Drosophila Scraps homolog); actin binding protein antibody; anillin; actin binding protein antibody; DKFZp779A055 antibody; scra antibody; Scraps; ANILLIN / Scraps (C Terminus)
 Product Gene Name   

anti-ANLN antibody

[Similar Products]
 Product Synonym Gene Name    ANILLIN [Similar Products]
 Antibody/Peptide Pairs    ANILLIN / Scraps peptide (MBS428552) is used for blocking the activity of ANILLIN/Scraps antibody (MBS421177)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    WQPDACYKPI GKP
 OMIM    616027
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence WQPDACYKPIGKP, from the C Terminus of the protein sequence according to NP_061155.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ANLN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ANLN antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-ANLN antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Kidney shows staining of nuclei in some cells of renal tubules. Recommended concentration, 3-10ug/ml.
Western Blot: Preliminary experiments gave an approx 75kDa band in Mouse Brain lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 124kDa according to NP_061155.2. The 75kDa band was successfully blocked by incubation with the immunizing peptide.
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 Immunohistochemistry (IHC) of anti-ANLN antibody    (10ug/ml) staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
anti-ANLN antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ANLN. It may not necessarily be applicable to this product.
 NCBI GI #    31657094
 NCBI GeneID    54443
 NCBI Accession #    NP_061155.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_018685.4 [Other Products]
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 UniProt Secondary Accession #    Q5CZ78; Q6NSK5; Q9H8Y4; Q9NVN9; Q9NVP0 [Other Products]
 UniProt Related Accession #    Q9NQW6 [Other Products]
 Molecular Weight    120,016 Da
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 NCBI Official Full Name    actin-binding protein anillin isoform 1
 NCBI Official Synonym Full Names    anillin actin binding protein
 NCBI Official Symbol    ANLN [Similar Products]
 NCBI Official Synonym Symbols   
scra; FSGS8; Scraps
[Similar Products]
 NCBI Protein Information    actin-binding protein anillin
 UniProt Protein Name    Actin-binding protein anillin
 Protein Family    Anillin
 UniProt Gene Name    ANLN [Similar Products]
 UniProt Entry Name    ANLN_HUMAN
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 NCBI Summary for ANLN    This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
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 UniProt Comments for ANLN    anillin: an actin binding protein that interacts with cleavage furrow proteins such as septins and may play a role in cytokinesis.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p15-p14

Cellular Component: actin cytoskeleton; cell-cell adherens junction; contractile ring; intracellular membrane-bound organelle; nucleoplasm

Molecular Function: actin binding

Biological Process: cytokinesis after mitosis; regulation of exit from mitosis; septin ring assembly

Disease: Focal Segmental Glomerulosclerosis 8
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 Research Articles on ANLN    1. Data suggest that anillin (ANLN) could be involved in breast cancer progression and a potential target candidate in breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ANLN antibodyDiseases associated with anti-ANLN antibody
 Products by Pathway  Pathway Diagram
 RB In Cancer Pathway antibodies  RB In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma, Squamous Cell Antibodies  >5 publications with ANLN and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >5 publications with ANLN and Adenocarcinoma
 Breast Neoplasms Antibodies  >4 publications with ANLN and Breast Neoplasms
 Lung Neoplasms Antibodies  >4 publications with ANLN and Lung Neoplasms
 Lung Diseases Antibodies  >4 publications with ANLN and Lung Diseases
 Cardiovascular Diseases Antibodies  >3 publications with ANLN and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >2 publications with ANLN and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with ANLN and Liver Diseases
 Neoplasm Metastasis Antibodies  >2 publications with ANLN and Neoplasm Metastasis
 Necrosis Antibodies  >2 publications with ANLN and Necrosis
Organs/Tissues associated with anti-ANLN antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with ANLN and Lung
 Blood Antibodies  >2 publications with ANLN and Blood
 Vascular Antibodies  >2 publications with ANLN and Vascular
 Liver Antibodies  >2 publications with ANLN and Liver
 Bladder Antibodies  >1 publications with ANLN and Bladder
 Intestine Antibodies  >1 publications with ANLN and Intestine
 Muscle Antibodies  >1 publications with ANLN and Muscle
 Skin Antibodies  >1 publications with ANLN and Skin
 Kidney Antibodies  >1 publications with ANLN and Kidney
 Stomach Antibodies  >1 publications with ANLN and Stomach
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