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anti-ANPEP antibody :: Rabbit anti-Human, Mouse ANPEP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051737
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ANPEP, Polyclonal Antibody

★Popular Item★
 Also Known As   

ANPEP Antibody

 Product Synonym Names    Aminopeptidase N; AP-N; hAPN; Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD13; ANPEP; APN; CD13; PEPN
 Product Gene Name   

anti-ANPEP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X13276 mRNA
 3D Structure    ModBase 3D Structure for P15144
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Aminopeptidase N protein (34-219AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ANPEP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ANPEP antibody

   Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
 Applications Tested/Suitable for anti-ANPEP antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ANPEP antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:50-1:200
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 Western Blot (WB) of anti-ANPEP antibody    Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: ANPEP antibody at 3.4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 110 KDa
Observed band size: 110 KDa

anti-ANPEP antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ANPEP antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7051737 at dilution of 1:100
anti-ANPEP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ANPEP antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7051737 at dilution of 1:100
anti-ANPEP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ANPEP antibody    Immunofluorescent analysis of HepG2 cells using MBS7051737 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ANPEP antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ANPEP. It may not necessarily be applicable to this product.
 NCBI GI #    157266300
 NCBI GeneID    290
 NCBI Accession #    NP_001141.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001150.2 [Other Products]
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 UniProt Primary Accession #    P15144 [Other Products]
 UniProt Secondary Accession #    Q16728; Q6GT90; Q8IUK3; Q8IVH3; Q9UCE0 [Other Products]
 UniProt Related Accession #    P15144 [Other Products]
 Molecular Weight    109,540 Da
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 NCBI Official Full Name    aminopeptidase N
 NCBI Official Synonym Full Names    alanyl aminopeptidase, membrane
 NCBI Official Symbol    ANPEP [Similar Products]
 NCBI Official Synonym Symbols   
APN; CD13; LAP1; P150; PEPN; GP150
[Similar Products]
 NCBI Protein Information    aminopeptidase N
 UniProt Protein Name    Aminopeptidase N
 UniProt Synonym Protein Names   
Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD_antigen: CD13
 Protein Family    Aminopeptidase
 UniProt Gene Name    ANPEP [Similar Products]
 UniProt Synonym Gene Names    APN; CD13; PEPN; AP-N; hAPN; AP-M [Similar Products]
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 NCBI Summary for ANPEP    Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANPEP    CD13: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. Belongs to the peptidase M1 family.

Protein type: EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc.

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: ER-Golgi intermediate compartment; extracellular space; integral to plasma membrane; lysosomal membrane

Molecular Function: aminopeptidase activity; metallopeptidase activity; peptide binding; receptor activity; zinc ion binding

Biological Process: peptide catabolic process
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 Research Articles on ANPEP    1. CD13 expression is associated with hepatoblastoma invasiveness and could be a novel prognostic marker for hepatoblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANPEP antibodyPathways associated with anti-ANPEP antibody
 Reference Product  PubMed Publications
 ENPEP antibody  >2 publications with ANPEP and ENPEP
 AGT antibody  >1 publications with ANPEP and AGT
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with anti-ANPEP antibodyOrgans/Tissues associated with anti-ANPEP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with ANPEP and Neoplasms
 Carcinoma Antibodies  >4 publications with ANPEP and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with ANPEP and Adenocarcinoma
 Hypertension Antibodies  >3 publications with ANPEP and Hypertension
 Cardiovascular Diseases Antibodies  >2 publications with ANPEP and Cardiovascular Diseases
 Vascular Diseases Antibodies  >2 publications with ANPEP and Vascular Diseases
 Immune System Diseases Antibodies  >2 publications with ANPEP and Immune System Diseases
 Nervous System Diseases Antibodies  >1 publications with ANPEP and Nervous System Diseases
 Fibrosis Antibodies  >1 publications with ANPEP and Fibrosis
 Breast Neoplasms Antibodies  >1 publications with ANPEP and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with ANPEP and Blood
 Bone Antibodies  >5 publications with ANPEP and Bone
 Embryonic Tissue Antibodies  >4 publications with ANPEP and Embryonic Tissue
 Prostate Antibodies  >3 publications with ANPEP and Prostate
 Kidney Antibodies  >3 publications with ANPEP and Kidney
 Uterus Antibodies  >3 publications with ANPEP and Uterus
 Bone Marrow Antibodies  >3 publications with ANPEP and Bone Marrow
 Vascular Antibodies  >3 publications with ANPEP and Vascular
 Connective Tissue Antibodies  >2 publications with ANPEP and Connective Tissue
 Pancreas Antibodies  >2 publications with ANPEP and Pancreas
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