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anti-ANXA1 antibody :: Rabbit ANXA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126626
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ANXA1, Polyclonal Antibody

 Also Known As   

ANXA1 Polyclonal Antibody

 Product Synonym Names    ANXA1; ANX1; LPC1
 Product Gene Name   

anti-ANXA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    151690
 3D Structure    ModBase 3D Structure for P04083
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human ANXA1
 Calculated Molecular Weight    39kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-ANXA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ANXA1 antibody

   The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with high biological and structural homology (1). Annexin-1 (ANXA1) is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis (2-4). Annexin A1 has anti-inflammatory properties and inhibits phospholipase A2 activity (5,6). Annexin A1 can accumulate on internalized vesicles after EGF-stimulated endocytosis and may be required for a late stage in inward vesiculation (7). Phosphorylation by PKC, EGFR, and Chak1 results in inhibition of annexin A1 function (8-10). Annexin A1 has also been identified as one of the 'eat-me' signals on apoptotic cells that are to be recognized and ingested by phagocytes (11). Annexin A1, as an endogenous anti-inflammatory mediator, has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, apoptosis, and tumorigenesis and cancer development (12-14).
 Product Categories/Family for anti-ANXA1 antibody    Polyclonal
 Applications Tested/Suitable for anti-ANXA1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ANXA1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
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 Western Blot (WB) of anti-ANXA1 antibody    Western blot analysis of HeLa cell and NIH3T3 cell lysate using ANXA1 antibody.
anti-ANXA1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC of anti-ANXA1 antibody    Immunohistochemistry of paraffin-embedded human endometrial cancer using ANXA1 antibody at dilution of 1:200 (400x lens).
anti-ANXA1 antibody Immunohistochemistry (IHC (IHC) image
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 Immunohistochemistry (IHC) of anti-ANXA1 antibody    Immunohistochemistry of paraffin-embedded human thyroid cancer using ANXA1 antibody at dilution of 1:200 (200x lens).
anti-ANXA1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ANXA1 antibody    Immunohistochemistry of paraffin-embedded rat brain using ANXA1 antibody at dilution of 1:200 (200x lens).
anti-ANXA1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ANXA1 antibody    Immunofluorescence analysis of HeLa cell using ANXA1 antibody. Blue: DAPI for nuclear staining.
anti-ANXA1 antibody Immunofluorescence (IF) image
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 Immunofluorescence (IF) of anti-ANXA1 antibody    Immunofluorescence analysis of HeLa cell using ANXA1 antibody. Blue: DAPI for nuclear staining.
anti-ANXA1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ANXA1. It may not necessarily be applicable to this product.
 NCBI GI #    113944
 NCBI GeneID    301
 NCBI Accession #    P04083.2 [Other Products]
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 UniProt Primary Accession #    P04083 [Other Products]
 UniProt Related Accession #    P04083 [Other Products]
 Molecular Weight    346
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 NCBI Official Full Name    Annexin A1
 NCBI Official Synonym Full Names    annexin A1
 NCBI Official Symbol    ANXA1 [Similar Products]
 NCBI Official Synonym Symbols   
ANX1; LPC1
[Similar Products]
 NCBI Protein Information    annexin A1; annexin-1; calpactin-2; calpactin II; chromobindin-9; annexin I (lipocortin I); phospholipase A2 inhibitory protein
 UniProt Protein Name    Annexin A1
 UniProt Synonym Protein Names   
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
 Protein Family    Annexin
 UniProt Gene Name    ANXA1 [Similar Products]
 UniProt Synonym Gene Names    ANX1; LPC1 [Similar Products]
 UniProt Entry Name    ANXA1_HUMAN
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 NCBI Summary for ANXA1    This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
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 UniProt Comments for ANXA1    ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: extracellular space; cell surface; protein complex; focal adhesion; mast cell granule; basolateral plasma membrane; extracellular region; cornified envelope; cilium; cytoplasm; mitochondrial membrane; plasma membrane; nucleus; vesicle; sarcolemma; endosome

Molecular Function: protein binding, bridging; protein binding; protein homodimerization activity; single-stranded RNA binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; double-stranded DNA-dependent ATPase activity; phospholipid binding; calcium ion binding; structural molecule activity; calcium-dependent protein binding; helicase activity; single-stranded DNA binding; receptor binding

Biological Process: response to drug; prostate gland development; response to peptide hormone stimulus; positive regulation of neutrophil apoptosis; gliogenesis; positive regulation of vesicle fusion; alpha-beta T cell differentiation; arachidonic acid secretion; neutrophil homeostasis; signal transduction; endocrine pancreas development; DNA duplex unwinding; response to estradiol stimulus; regulation of cell proliferation; keratinocyte differentiation; cell surface receptor linked signal transduction; insulin secretion; DNA strand renaturation; peptide cross-linking; cell motility; inflammatory response; positive regulation of prostaglandin biosynthetic process; negative regulation of apoptosis; response to X-ray
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 Research Articles on ANXA1    1. These data show a multiantibody composition in lupus nephritis, where IgG2 autoantibodies against alpha-enolase and annexin AI predominate in the glomerulus and can be detected in serum.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANXA1 antibodyPathways associated with anti-ANXA1 antibody
 Reference Product  PubMed Publications
 FPR2 antibody  >24 publications with ANXA1 and FPR2
 FPR1 antibody  >14 publications with ANXA1 and FPR1
 POMC antibody  >11 publications with ANXA1 and POMC
 S100A11 antibody  >5 publications with ANXA1 and S100A11
 FPR3 antibody  >3 publications with ANXA1 and FPR3
 S100A6 antibody  >2 publications with ANXA1 and S100A6
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies  Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with anti-ANXA1 antibodyOrgans/Tissues associated with anti-ANXA1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >79 publications with ANXA1 and Inflammation
 Carcinoma Antibodies  >57 publications with ANXA1 and Carcinoma
 Disease Models, Animal Antibodies  >25 publications with ANXA1 and Disease Models, Animal
 Brain Diseases Antibodies  >19 publications with ANXA1 and Brain Diseases
 Neoplasm Metastasis Antibodies  >18 publications with ANXA1 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >17 publications with ANXA1 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >16 publications with ANXA1 and Lung Diseases
 Cardiovascular Diseases Antibodies  >12 publications with ANXA1 and Cardiovascular Diseases
 Necrosis Antibodies  >12 publications with ANXA1 and Necrosis
 Stomach Diseases Antibodies  >10 publications with ANXA1 and Stomach Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >90 publications with ANXA1 and Blood
 Brain Antibodies  >29 publications with ANXA1 and Brain
 Lung Antibodies  >23 publications with ANXA1 and Lung
 Vascular Antibodies  >21 publications with ANXA1 and Vascular
 Liver Antibodies  >15 publications with ANXA1 and Liver
 Pituitary Gland Antibodies  >13 publications with ANXA1 and Pituitary Gland
 Stomach Antibodies  >11 publications with ANXA1 and Stomach
 Lymph Node Antibodies  >11 publications with ANXA1 and Lymph Node
 Bone Antibodies  >10 publications with ANXA1 and Bone
 Muscle Antibodies  >10 publications with ANXA1 and Muscle
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