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anti-ANXA2 antibody :: Rabbit ANXA2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9607124
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
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 Product Name   

ANXA2, Polyclonal Antibody

★Popular Item★
 Also Known As   

ANXA2 Antibody

 Product Synonym Names    Annexin A2; Annexin II; Annexin II, heavy chain; Annexin-2; ANX 2; ANX2; ANX2L4; ANXA2; ANXA2_HUMAN; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); Calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; Epididymis secretory protein Li 270; HEL S 270; LIP2; Lipocortin II; LPC2; LPC2D; p36; P36 protein; PAP-IV; Placental anticoagulant protein IV; Protein I
 Product Gene Name   

anti-ANXA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P07355
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    ANXA2 antibody detects endogenous levels of total ANXA2
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide derived from human ANXA2
 Subcellular Location    Secreted > Extracellular Space > Extracellular Matrix > Basement Membrane. Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a golgi-independent mechanism.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-ANXA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ANXA2 antibody

   Description: Annexin A2 (ANXA2), also known as lipocortin II or calpactin-1 heavy chain, is a 36 kDa member of the annexin superfamily that binds phospholipids and other proteins in a calcium-dependent manner via annexin repeats (1). Annexin A2 contains four such repeats through which it mediates protein-protein and protein-lipid interactions (1-4). It forms a constitutive heterotetramer with S100A10, acting as a bridge between the actin cytoskeleton, plasma membrane, and endocytotic vesicle machinery (5-7). Originally identified as a protein inhibitor of phospholipase A2, annexin A2 has subsequently been shown to interact with an array of protein and non-protein partners, including F-actin, spectrin, SNARE complexes, RNA, and virus particles (4, 6, 8, 9). Annexin A2 has also been shown to have receptor-like activity and is detected on the surface of macrophages and vascular endothelial cells where it mediates macrophage activation and Factor Xa signaling, respectively (10-13). Upregulation of annexin A2 at the cell surface is thought to be modulated by phosphorylation at Tyr23 by Src (14-18). Interestingly, phosphorylation at Tyr23 has recently been shown to be required for cell surface expression of annexin A2 where it mediates motility, invasiveness, and overall metastatic potential of certain pancreatic cancer cells (19, 20).
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
Subunit Structure: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH (PubMed:21886777). Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR (PubMed:18799458). Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (PubMed:14522961).
Post-translational Modifications: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.
Similarity: A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family.
 Applications Tested/Suitable for anti-ANXA2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-ANXA2 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-ANXA2 antibody    MBS9607124 at 1/100 staining Human uterus tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-ANXA2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ANXA2 antibody    Western blot analysis of extracts of A2058, using ANXA2 antibody. The lane on the left is treated with the antigen-specific peptide.
anti-ANXA2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ANXA2. It may not necessarily be applicable to this product.
 NCBI GI #    50845386
 NCBI GeneID    302
 NCBI Accession #    NP_001002857.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002857.1 [Other Products]
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 UniProt Primary Accession #    P07355 [Other Products]
 UniProt Secondary Accession #    Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8 [Other Products]
 UniProt Related Accession #    P07355 [Other Products]
 Molecular Weight    Observed: 39 kDa
Predicted: 39 kDa
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 NCBI Official Full Name    annexin A2 isoform 2
 NCBI Official Synonym Full Names    annexin A2
 NCBI Official Symbol    ANXA2 [Similar Products]
 NCBI Official Synonym Symbols   
P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
[Similar Products]
 NCBI Protein Information    annexin A2
 UniProt Protein Name    Annexin A2
 UniProt Synonym Protein Names   
Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
 Protein Family    Annexin
 UniProt Gene Name    ANXA2 [Similar Products]
 UniProt Synonym Gene Names    ANX2; ANX2L4; CAL1H; LPC2D; PAP-IV [Similar Products]
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 NCBI Summary for ANXA2    This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANXA2    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
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 Research Articles on ANXA2    1. aptamer wh6 can block MM cell adhesion to ANXA2 and block the proliferation of MM cells induced by ANXA2
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ANXA2 antibodyPathways associated with anti-ANXA2 antibody
 Reference Product  PubMed Publications
 S100A10 antibody  >27 publications with ANXA2 and S100A10
 SRC antibody  >8 publications with ANXA2 and SRC
 PLG antibody  >4 publications with ANXA2 and PLG
 S100A6 antibody  >4 publications with ANXA2 and S100A6
 S100A4 antibody  >2 publications with ANXA2 and S100A4
 PLAT antibody  >2 publications with ANXA2 and PLAT
 CDC42 antibody  >2 publications with ANXA2 and CDC42
 PHB antibody  >1 publications with ANXA2 and PHB
 GRB2 antibody  >1 publications with ANXA2 and GRB2
 DYSF antibody  >1 publications with ANXA2 and DYSF
 Products by Pathway  Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
Diseases associated with anti-ANXA2 antibodyOrgans/Tissues associated with anti-ANXA2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >71 publications with ANXA2 and Neoplasms
 Adenocarcinoma Antibodies  >20 publications with ANXA2 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >15 publications with ANXA2 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >15 publications with ANXA2 and Cardiovascular Diseases
 Inflammation Antibodies  >15 publications with ANXA2 and Inflammation
 Liver Diseases Antibodies  >14 publications with ANXA2 and Liver Diseases
 Neoplasm Invasiveness Antibodies  >13 publications with ANXA2 and Neoplasm Invasiveness
 Necrosis Antibodies  >12 publications with ANXA2 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >11 publications with ANXA2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >11 publications with ANXA2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with ANXA2 and Blood
 Vascular Antibodies  >29 publications with ANXA2 and Vascular
 Bone Antibodies  >27 publications with ANXA2 and Bone
 Liver Antibodies  >22 publications with ANXA2 and Liver
 Lung Antibodies  >13 publications with ANXA2 and Lung
 Brain Antibodies  >12 publications with ANXA2 and Brain
 Muscle Antibodies  >11 publications with ANXA2 and Muscle
 Prostate Antibodies  >9 publications with ANXA2 and Prostate
 Bone Marrow Antibodies  >9 publications with ANXA2 and Bone Marrow
 Connective Tissue Antibodies  >8 publications with ANXA2 and Connective Tissue
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