NP_000029.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
adenomatous polyposis coli protein isoform b
NCBI Official Synonym Full Names
APC, WNT signaling pathway regulator
NCBI Official Synonym Symbols
GS; DP2; DP3; BTPS2; DP2.5; PPP1R46 [Similar Products]
NCBI Protein Information
adenomatous polyposis coli protein
UniProt Protein Name
Adenomatous polyposis coli protein
UniProt Synonym Protein Names
Deleted in polyposis 2.5
UniProt Synonym Gene Names
NCBI Summary for APC
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
UniProt Comments for APC
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
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Products associated with anti-APC antibody
Pathways associated with anti-APC antibody
Diseases associated with anti-APC antibody
Organs/Tissues associated with anti-APC antibody
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