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anti-APG5 antibody :: Rabbit APG5 / ATG5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241734
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APG5 / ATG5, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human APG5 / ATG5

 Product Synonym Names    Anti-APG5 / ATG5 Antibody IHC-plus; ATG5; APG5; APG5-LIKE; APG5L; Apoptosis specific protein; Apoptosis-specific protein; Autophagy related 5; HAPG5; ASP; Autophagy protein 5; Human APG5; ATG5
 Product Gene Name   

anti-APG5 antibody

[Similar Products]
 Product Synonym Gene Name    ATG5 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604261
 3D Structure    ModBase 3D Structure for Q9H1Y0
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bovine, Human, Mouse, Pufferfish, Pig, Rat, Zebrafish
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 Specificity    A portion of amino acid 1-50 of human APG5L
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.2% gelatin, 0.05% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human ATG5.
 Immunogen Type    Synthetic peptide
 Immunogen    APG5 / ATG5 antibody was raised against synthetic peptide from human ATG5.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-APG5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-APG5 antibody

   ATG5 is required for the process of autophagy, an intracellular process for bulk degradation of cytoplasmic components. ATG5 conjugates to ATG12 and associates with isolation membranes to form autophagosomes. The autophagosomes then enclose cytoplasmic components and deliver them to lysosomes/vacuoles to be degraded. ATG5 has been shown to be involved in apoptosis with expression late in the apoptotic process downstream of caspase activity.
 Applications Tested/Suitable for anti-APG5 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-APG5 antibody    IHC-P (5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-APG5 antibody    Anti-ATG5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-APG5 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-APG5 antibody    Western blot of human APGL5 in T98G cell lysate in the 1) absence, 2) presence of immunizing peptide using antibody at 1 ug/ml.
anti-APG5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for APG5. It may not necessarily be applicable to this product.
 NCBI GI #    4757798
 NCBI GeneID    9474
 NCBI Accession #    NP_004840.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004849.3 [Other Products]
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 UniProt Primary Accession #    Q9H1Y0 [Other Products]
 UniProt Secondary Accession #    O60875; Q5JVR2; Q68DI4; Q9H2B8; Q9HCZ7 [Other Products]
 UniProt Related Accession #    Q9H1Y0 [Other Products]
 Molecular Weight    22,931 Da
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 NCBI Official Full Name    autophagy protein 5 isoform a
 NCBI Official Synonym Full Names    autophagy related 5
 NCBI Official Symbol    ATG5 [Similar Products]
 NCBI Official Synonym Symbols   
ASP; APG5; APG5L; hAPG5; APG5-LIKE
[Similar Products]
 NCBI Protein Information    autophagy protein 5; apoptosis-specific protein; ATG5 autophagy related 5 homolog
 UniProt Protein Name    Autophagy protein 5
 UniProt Synonym Protein Names   
APG5-like; Apoptosis-specific protein
 UniProt Gene Name    ATG5 [Similar Products]
 UniProt Synonym Gene Names    APG5L; ASP [Similar Products]
 UniProt Entry Name    ATG5_HUMAN
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 UniProt Comments for APG5    ATG5: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Apoptosis; Autophagy

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: membrane; cytoplasm; pre-autophagosomal structure membrane; autophagic vacuole; axoneme

Molecular Function: protein binding; APG8 conjugating enzyme activity

Biological Process: response to drug; response to fungus; apoptosis; ventricular cardiac muscle cell development; C-terminal protein lipidation; post-translational protein modification; vasodilation; regulation of release of sequestered calcium ion into cytosol; cellular response to nitrogen starvation; heart contraction; regulation of cytokine secretion during immune response; mitochondrion degradation; innate immune response; autophagy; blood vessel remodeling; negative regulation of protein ubiquitination; negative regulation of interferon type I production; otolith development; negative regulation of apoptosis; autophagic vacuole formation
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 Research Articles on APG5    1. both autophagy-related 5 and microtubule-associated protein 1 light chain 3B levels are decreased in patients with melanomas as compared with those with benign nevi
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APG5 antibodyPathways associated with anti-APG5 antibody
 Reference Product  PubMed Publications
 ATG12 antibody  >221 publications with APG5 and ATG12
 BECN1 antibody  >191 publications with APG5 and BECN1
 ATG3 antibody  >53 publications with APG5 and ATG3
 ATG16L1 antibody  >48 publications with APG5 and ATG16L1
 CASP8 antibody  >26 publications with APG5 and CASP8
 FADD antibody  >21 publications with APG5 and FADD
 SIRT1 antibody  >8 publications with APG5 and SIRT1
 DDX58 antibody  >5 publications with APG5 and DDX58
 MAVS antibody  >4 publications with APG5 and MAVS
 WDFY3 antibody  >1 publications with APG5 and WDFY3
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies  RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Shigellosis Pathway antibodies  Shigellosis Pathway Diagram
Diseases associated with anti-APG5 antibodyOrgans/Tissues associated with anti-APG5 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >57 publications with APG5 and Necrosis
 Inflammation Antibodies  >55 publications with APG5 and Inflammation
 Cardiovascular Diseases Antibodies  >54 publications with APG5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >47 publications with APG5 and Disease Models, Animal
 Liver Diseases Antibodies  >41 publications with APG5 and Liver Diseases
 Gastrointestinal Diseases Antibodies  >34 publications with APG5 and Gastrointestinal Diseases
 Heart Diseases Antibodies  >34 publications with APG5 and Heart Diseases
 Carcinoma, Hepatocellular Antibodies  >27 publications with APG5 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >25 publications with APG5 and Breast Neoplasms
 Liver Neoplasms Antibodies  >24 publications with APG5 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >89 publications with APG5 and Blood
 Brain Antibodies  >87 publications with APG5 and Brain
 Liver Antibodies  >69 publications with APG5 and Liver
 Muscle Antibodies  >59 publications with APG5 and Muscle
 Lung Antibodies  >58 publications with APG5 and Lung
 Heart Antibodies  >52 publications with APG5 and Heart
 Kidney Antibodies  >35 publications with APG5 and Kidney
 Eye Antibodies  >30 publications with APG5 and Eye
 Bone Antibodies  >30 publications with APG5 and Bone
 Prostate Antibodies  >25 publications with APG5 and Prostate
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