NP_004840.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,931 Da
NCBI Official Full Name
autophagy protein 5 isoform a
NCBI Official Synonym Full Names
autophagy related 5
NCBI Official Synonym Symbols
ASP; APG5; APG5L; hAPG5; APG5-LIKE [Similar Products]
NCBI Protein Information
autophagy protein 5; apoptosis-specific protein; ATG5 autophagy related 5 homolog
UniProt Protein Name
Autophagy protein 5
UniProt Synonym Protein Names
APG5-like; Apoptosis-specific protein
UniProt Synonym Gene Names
UniProt Entry Name
ATG5_HUMAN
UniProt Comments for APG5
ATG5: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Apoptosis; Autophagy
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: membrane; cytoplasm; pre-autophagosomal structure membrane; autophagic vacuole; axoneme
Molecular Function: protein binding; APG8 conjugating enzyme activity
Biological Process: response to drug; response to fungus; apoptosis; ventricular cardiac muscle cell development; C-terminal protein lipidation; post-translational protein modification; vasodilation; regulation of release of sequestered calcium ion into cytosol; cellular response to nitrogen starvation; heart contraction; regulation of cytokine secretion during immune response; mitochondrion degradation; innate immune response; autophagy; blood vessel remodeling; negative regulation of protein ubiquitination; negative regulation of interferon type I production; otolith development; negative regulation of apoptosis; autophagic vacuole formation
Research Articles on APG5
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Products associated with anti-APG5 antibody
Pathways associated with anti-APG5 antibody
Diseases associated with anti-APG5 antibody
Organs/Tissues associated with anti-APG5 antibody
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