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anti-APIP antibody :: Rabbit anti-Human, Mouse APIP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044091
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APIP, Polyclonal Antibody

★Popular Item★
 Also Known As   

APIP Antibody

 Product Synonym Names    Methylthioribulose-1-phosphate dehydratase; APAF1-interacting protein; APIP
 Product Gene Name   

anti-APIP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612491
 3D Structure    ModBase 3D Structure for Q96GX9
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Methylthioribulose-1-phosphate dehydratase protein (1-242AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66318 / sc-66319 / sc-292256
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-APIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-APIP antibody

   Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
 Applications Tested/Suitable for anti-APIP antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-APIP antibody    Western blot
All lanes:  APIPantibody at 1.85ug/ml
Lane 1 : Mouse heart tissue
Lane 2 : Mouse kidney tissue
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 28,23 kDa
Observed band size: 27 kDa

anti-APIP antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-APIP antibody    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7044091 at dilution 1:100
anti-APIP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-APIP antibody    Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7044091 at dilution 1:100
anti-APIP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for APIP. It may not necessarily be applicable to this product.
 NCBI GI #    166235186
 NCBI GeneID    51074
 NCBI Accession #    NP_057041.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015957.3 [Other Products]
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 UniProt Primary Accession #    Q96GX9 [Other Products]
 UniProt Secondary Accession #    Q6PJX6; Q8WVU2; Q96HK2; Q9Y318; A8K9D3 [Other Products]
 UniProt Related Accession #    Q96GX9 [Other Products]
 Molecular Weight    22,858 Da
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 NCBI Official Full Name    methylthioribulose-1-phosphate dehydratase
 NCBI Official Synonym Full Names    APAF1 interacting protein
 NCBI Official Symbol    APIP [Similar Products]
 NCBI Official Synonym Symbols   
APIP2; CGI29; hAPIP; CGI-29; MMRP19
[Similar Products]
 NCBI Protein Information    methylthioribulose-1-phosphate dehydratase
 UniProt Protein Name    Methylthioribulose-1-phosphate dehydratase
 UniProt Synonym Protein Names   
APAF1-interacting protein
 UniProt Gene Name    APIP [Similar Products]
 UniProt Synonym Gene Names    MTRu-1-P dehydratase; hAPIP [Similar Products]
 UniProt Entry Name    MTNB_HUMAN
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 NCBI Summary for APIP    APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
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 UniProt Comments for APIP    MMRP19: Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c- dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Amino Acid Metabolism - cysteine and methionine; EC 4.2.1.109

Chromosomal Location of Human Ortholog: 11p13

Molecular Function: identical protein binding; protein binding

Biological Process: methionine salvage; negative regulation of apoptosis
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 Research Articles on APIP    1. APIP/MtnB functions as a cell death inhibitor independently of its MtnB enzyme activity for apoptosis induced by either hypoxia or etoposide, but dependently for caspase-1-induced pyroptosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APIP antibodyPathways associated with anti-APIP antibody
 Reference Product  PubMed Publications
 CASP9 antibody  >8 publications with APIP and CASP9
 APAF1 antibody  >5 publications with APIP and APAF1
 MTAP antibody  >1 publications with APIP and MTAP
 Products by Pathway  Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation Pathway antibodies  S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation Pathway Diagram
Diseases associated with anti-APIP antibodyOrgans/Tissues associated with anti-APIP antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >2 publications with APIP and Fibrosis
 Inflammation Antibodies  >2 publications with APIP and Inflammation
 Pregnancy Complications Antibodies  >1 publications with APIP and Pregnancy Complications
 Liver Diseases Antibodies  >1 publications with APIP and Liver Diseases
 Neoplasm Metastasis Antibodies  >1 publications with APIP and Neoplasm Metastasis
 Necrosis Antibodies  >1 publications with APIP and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6 publications with APIP and Lung
 Thymus Antibodies  >1 publications with APIP and Thymus
 Prostate Antibodies  >1 publications with APIP and Prostate
 Liver Antibodies  >1 publications with APIP and Liver
 Pancreas Antibodies  >1 publications with APIP and Pancreas
 Muscle Antibodies  >1 publications with APIP and Muscle
 Kidney Antibodies  >1 publications with APIP and Kidney
 Bone Marrow Antibodies  >1 publications with APIP and Bone Marrow
 Placenta Antibodies  >1 publications with APIP and Placenta
 Bone Antibodies  >1 publications with APIP and Bone
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