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anti-APLNR antibody :: Rabbit anti-Human APLNR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7005599
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APLNR, Polyclonal Antibody

★Popular Item★
 Also Known As   

APLNR Antibody

 Product Synonym Names    Apelin receptor; APLNR; AGTRL1; APJ; Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11
 Product Gene Name   

anti-APLNR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600052
 3D Structure    ModBase 3D Structure for P35414
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Apelin receptor protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-33838 / sc-33823
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-APLNR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-APLNR antibody

   Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
 Applications Tested/Suitable for anti-APLNR antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-APLNR antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-APLNR antibody    Immunohistochemistry of paraffin-embedded human colon cancer tissue using MBS7005599 at dilution 1:100
anti-APLNR antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-APLNR antibody    Immunofluorescent analysis of A431 cells using MBS7005599 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-APLNR antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for APLNR. It may not necessarily be applicable to this product.
 NCBI GI #    4885057
 NCBI GeneID    187
 NCBI Accession #    NP_005152.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005161.4 [Other Products]
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 UniProt Primary Accession #    P35414 [Other Products]
 UniProt Related Accession #    P35414 [Other Products]
 Molecular Weight    42,660 Da
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 NCBI Official Full Name    apelin receptor
 NCBI Official Synonym Full Names    apelin receptor
 NCBI Official Symbol    APLNR [Similar Products]
 NCBI Official Synonym Symbols   
APJ; APJR; HG11; AGTRL1
[Similar Products]
 NCBI Protein Information    apelin receptor
 UniProt Protein Name    Apelin receptor
 UniProt Synonym Protein Names   
Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11
 Protein Family    Apelin receptor
 UniProt Gene Name    APLNR [Similar Products]
 UniProt Synonym Gene Names    AGTRL1; APJ [Similar Products]
 UniProt Entry Name    APJ_HUMAN
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 NCBI Summary for APLNR    This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
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 UniProt Comments for APLNR    AGTRL1: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; gastrulation; heart development; regulation of body fluid levels
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 Research Articles on APLNR    1. apelin is produced by arterial endothelial cells (ECs) during embryogenesis, induces chemotaxis of venous ECs, and promotes the production of secreted Frizzled-related protein 1 by apelin receptor(+) ECs
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APLNR antibodyPathways associated with anti-APLNR antibody
 Reference Product  PubMed Publications
 APLN antibody  >184 publications with APLNR and APLN
 CXCR6 antibody  >1 publications with APLNR and CXCR6
 GRM8 antibody  >1 publications with APLNR and GRM8
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-APLNR antibodyOrgans/Tissues associated with anti-APLNR antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >89 publications with APLNR and Cardiovascular Diseases
 Vascular Diseases Antibodies  >66 publications with APLNR and Vascular Diseases
 Hypertension Antibodies  >44 publications with APLNR and Hypertension
 Heart Diseases Antibodies  >44 publications with APLNR and Heart Diseases
 Disease Models, Animal Antibodies  >27 publications with APLNR and Disease Models, Animal
 Hypertrophy Antibodies  >16 publications with APLNR and Hypertrophy
 Nervous System Diseases Antibodies  >16 publications with APLNR and Nervous System Diseases
 Inflammation Antibodies  >15 publications with APLNR and Inflammation
 Lung Diseases Antibodies  >15 publications with APLNR and Lung Diseases
 Kidney Diseases Antibodies  >11 publications with APLNR and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >109 publications with APLNR and Blood
 Heart Antibodies  >88 publications with APLNR and Heart
 Brain Antibodies  >43 publications with APLNR and Brain
 Kidney Antibodies  >24 publications with APLNR and Kidney
 Lung Antibodies  >21 publications with APLNR and Lung
 Embryonic Tissue Antibodies  >15 publications with APLNR and Embryonic Tissue
 Connective Tissue Antibodies  >14 publications with APLNR and Connective Tissue
 Adipose Tissue Antibodies  >14 publications with APLNR and Adipose Tissue
 Eye Antibodies  >8 publications with APLNR and Eye
 Ovary Antibodies  >6 publications with APLNR and Ovary
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