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anti-APOBEC1 antibody :: Goat APOBEC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421886
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APOBEC1, Polyclonal Antibody

 Also Known As   

Goat anti-APOBEC1 Antibody

 Product Synonym Names    APOBEC1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; APOBEC-1; BEDP; CDAR1; HEPR; apolipoprotein B mRNA editing enzyme; apolipoprotein B mRNA editing enzyme complex-1; APOBEC1 antibody; apolipoprotein B mRNA editing enzyme; catalytic polypeptide 1 antibody; APOBEC-1 antibody; BEDP antibody; CDAR1 antibody; HEPR antibody; apolipoprotein B mRNA editing enzyme antibody; apolipoprotein B mRNA editing enzyme complex-1 antibody
 Product Gene Name   

anti-APOBEC1 antibody

[Similar Products]
 Antibody/Peptide Pairs    APOBEC1 peptide (MBS425185) is used for blocking the activity of APOBEC1 antibody (MBS421886)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DVFYDPRELR KEAC
 OMIM    600130
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse; Expected from sequence similarity: Human, Mouse
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence DVFYDPRELRKEAC, from the internal region (near N Terminus) of the protein sequence according to NP_001635.2.
 Epitope    Internal region (near N Terminus)
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-APOBEC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-APOBEC1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-APOBEC1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx.28kDa band observed in Mouse Spleen lysates (calculated MW of 28.2kDa according to Human NP_001635.2 and 27.5kDa acccording to Mouse NP_112436.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-APOBEC1 antibody    (1ug/ml) staining of Mouse Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-APOBEC1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for APOBEC1. It may not necessarily be applicable to this product.
 NCBI GI #    61743957
 NCBI GeneID    339
 NCBI Accession #    NP_001635.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001644.4 [Other Products]
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 UniProt Secondary Accession #    Q9UE64; Q9UM71 [Other Products]
 UniProt Related Accession #    P41238 [Other Products]
 Molecular Weight    28,192 Da
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 NCBI Official Full Name    C->U-editing enzyme APOBEC-1 isoform a
 NCBI Official Synonym Full Names    apolipoprotein B mRNA editing enzyme catalytic subunit 1
 NCBI Official Symbol    APOBEC1 [Similar Products]
 NCBI Official Synonym Symbols   
BEDP; HEPR; CDAR1; APOBEC-1
[Similar Products]
 NCBI Protein Information    C->U-editing enzyme APOBEC-1
 UniProt Protein Name    C->U-editing enzyme APOBEC-1
 UniProt Synonym Protein Names   
Apolipoprotein B mRNA-editing enzyme 1; HEPR; mRNA(cytosine(6666)) deaminase 1
 Protein Family    APOBEC1 complementation factor
 UniProt Gene Name    APOBEC1 [Similar Products]
 UniProt Entry Name    ABEC1_HUMAN
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 NCBI Summary for APOBEC1    This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
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 UniProt Comments for APOBEC1    APOBEC1: apolipoprotein B mRNA editing enzyme. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. Expressed exclusively in the small intestine.

Protein type: Cell cycle regulation; RNA processing; Hydrolase; RNA-binding; EC 3.5.4.-

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: AU-rich element binding; cytidine deaminase activity; cytosine deaminase activity; enzyme activator activity; mRNA binding; protein binding; protein domain specific binding; ribonucleoprotein binding; RNA binding; zinc ion binding

Biological Process: cellular response to insulin stimulus; cytidine deamination; cytidine to uridine editing; defense response to virus; lipid metabolic process; lipoprotein biosynthetic process; lipoprotein transport; mRNA modification; mRNA processing; mRNA stabilization; positive regulation of catalytic activity; regulation of cell proliferation; response to calcium ion; response to drug; response to ethanol; response to gamma radiation; response to osmotic stress; response to zinc ion; RNA processing
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 Research Articles on APOBEC1    1. Results show that expression of APOBEC1 induces a mutator phenotype in 2 different cellular models.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-APOBEC1 antibodyDiseases associated with anti-APOBEC1 antibody
 Products by Pathway  Pathway Diagram
 Formation Of The Editosome Pathway antibodies  Formation Of The Editosome Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 MRNA Editing Pathway antibodies  MRNA Editing Pathway Diagram
 MRNA Editing: C To U Conversion Pathway antibodies  MRNA Editing: C To U Conversion Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >4 publications with APOBEC1 and Heart Diseases
 Nervous System Diseases Antibodies  >3 publications with APOBEC1 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with APOBEC1 and Inflammation
 Neoplasms, Experimental Antibodies  >2 publications with APOBEC1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >2 publications with APOBEC1 and Liver Diseases
 Adenocarcinoma Antibodies  >2 publications with APOBEC1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with APOBEC1 and Carcinoma, Hepatocellular
 Testicular Diseases Antibodies  >2 publications with APOBEC1 and Testicular Diseases
 Fibrosis Antibodies  >1 publications with APOBEC1 and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >1 publications with APOBEC1 and Cell Transformation, Neoplastic
Organs/Tissues associated with anti-APOBEC1 antibody
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >12 publications with APOBEC1 and Intestine
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