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anti-APOBEC3A antibody :: Rabbit anti-Human APOBEC3A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493785 anti-APOBEC3A antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APOBEC3A, Polyclonal Antibody

★Popular Item★
 Also Known As   

APOBEC3A Antibody, HRP conjugated

 Product Synonym Names    DNA dC->dU-editing enzyme APOBEC-3A (EC:3.5.4.-); A3A; APOBEC3A; Phorbolin-1
 Product Gene Name   

anti-APOBEC3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607109
 3D Structure    ModBase 3D Structure for P31941
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    HRP
 Immunogen    Recombinant human DNA dC->dU-editing enzyme APOBEC-3A protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-130688
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-APOBEC3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-APOBEC3A antibody

   DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
 Applications Tested/Suitable for anti-APOBEC3A antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for APOBEC3A. It may not necessarily be applicable to this product.
 NCBI GI #    300869638
 NCBI GeneID    100913187
 NCBI Accession #    NP_001180218.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193289.1 [Other Products]
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 UniProt Primary Accession #    P31941 [Other Products]
 UniProt Secondary Accession #    Q12807; Q5JZ93; Q9UH18; A0AVM1 [Other Products]
 Molecular Weight    21,778 Da
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 NCBI Official Full Name    probable DNA dC->dU-editing enzyme APOBEC-3A
 NCBI Official Synonym Full Names    APOBEC3A and APOBEC3B deletion hybrid
 NCBI Official Symbol    APOBEC3A_B [Similar Products]
 NCBI Protein Information    probable DNA dC->dU-editing enzyme APOBEC-3A
 UniProt Protein Name    DNA dC->dU-editing enzyme APOBEC-3A
 UniProt Synonym Protein Names   
Phorbolin-1
 Protein Family    DNA dC->dU-editing enzyme
 UniProt Gene Name    APOBEC3A [Similar Products]
 UniProt Synonym Gene Names    A3A [Similar Products]
 UniProt Entry Name    ABC3A_HUMAN
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 NCBI Summary for APOBEC3A    This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. [provided by RefSeq, Jul 2012]
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 UniProt Comments for APOBEC3A    APOBEC3A: a single-stranded DNA cytidine deaminase involved in foreign DNA clearance with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic C-to-U hypermutation in nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Interacts with AGO2. Interacts with TRIB3. Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. Up-regulated by interferon and CpG single-stranded DNA (at protein level). Belongs to the cytidine and deoxycytidylate deaminase family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: EC 3.5.4.-; Hydrolase

Chromosomal Location of Human Ortholog: 22q13.1-q13.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: cytidine deaminase activity; deoxycytidine deaminase activity; protein binding; zinc ion binding

Biological Process: cytidine deamination; defense response to virus; innate immune response; negative regulation of viral genome replication
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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