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anti-APOBEC3C antibody :: Rabbit anti-Human, Mouse APOBEC3C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9609193
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APOBEC3C, Polyclonal Antibody

★Popular Item★
 Also Known As   

APOBEC3C Antibody

 Product Synonym Names    A3C; ABC3C_HUMAN; APOBEC1 like; APOBEC1-like; APOBEC1L; APOBEC3C; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C; ARDC2; ARDC4; ARP5; bK150C2.3; DNA dC > dU editing enzyme APOBEC 3C; MGC19485; PBI; Phorbolin I; Phorbolin I protein; Probable DNA dC dU editing enzyme APOBEC 3C; Probable DNA dC-> dU-editing enzyme APOBEC-3C
 Product Gene Name   

anti-APOBEC3C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9NRW3
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    APOBEC3C antibody detects endogenous levels of total APOBEC3C
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide derived from human APOBEC3C
 Subcellular Location    Nucleus
 Tissue Specificity    Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-APOBEC3C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-APOBEC3C antibody

   Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Subunit Structure: Homodimer. Interacts with human foamy virus protein Bet; this interaction does not induce APOBEC3C degradation, but prevents dimerization and incorporation into virion of the latter. Interacts with TRIB3 and AGO2.
Similarity: Belongs to the cytidine and deoxycytidylate deaminase family.
 Applications Tested/Suitable for anti-APOBEC3C antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-APOBEC3C antibody    WB: 1:1000-3000
IHC: 1:200
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 Immunohistochemistry (IHC) of anti-APOBEC3C antibody    MBS9609193 at 1/100 staining Mouse spleen tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-APOBEC3C antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-APOBEC3C antibody    Western blot analysis of APOBEC3C using COLO205 whole cell lysates
anti-APOBEC3C antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for APOBEC3C. It may not necessarily be applicable to this product.
 NCBI GI #    22907039
 NCBI GeneID    27350
 NCBI Accession #    NP_055323.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_014508.2 [Other Products]
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 UniProt Primary Accession #    Q9NRW3 [Other Products]
 UniProt Secondary Accession #    Q5JZ92; Q7Z2N7; Q96F12; B2R884 [Other Products]
 UniProt Related Accession #    Q9NRW3 [Other Products]
 Molecular Weight    Observed: 23 kDa
Predicted: 23 kDa
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 NCBI Official Full Name    DNA dC->dU-editing enzyme APOBEC-3C
 NCBI Official Synonym Full Names    apolipoprotein B mRNA editing enzyme catalytic subunit 3C
 NCBI Official Symbol    APOBEC3C [Similar Products]
 NCBI Official Synonym Symbols   
A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3
[Similar Products]
 NCBI Protein Information    DNA dC->dU-editing enzyme APOBEC-3C
 UniProt Protein Name    DNA dC->dU-editing enzyme APOBEC-3C
 UniProt Synonym Protein Names   
APOBEC1-like; Phorbolin I
 Protein Family    DNA dC->dU-editing enzyme
 UniProt Gene Name    APOBEC3C [Similar Products]
 UniProt Synonym Gene Names    APOBEC1L; PBI; A3C [Similar Products]
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 NCBI Summary for APOBEC3C    This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APOBEC3C    DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
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 Research Articles on APOBEC3C    1. Data suggest that heat shock proteins, in particular Hsp90, stimulate APOBEC3-mediated DNA deamination activity toward hepatitis B viral DNA, suggesting a potential physiological role in mutagenesis/carcinogenesis and viral innate immunity; Hsp90 stimulates deamination activity of APOBEC3G, APOBEC3B, and APOBEC3C during co-expression in human liver HepG2 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOBEC3C antibodyDiseases associated with anti-APOBEC3C antibody
 Reference Product  PubMed Publications
 APOBEC3F antibody  >24 publications with APOBEC3C and APOBEC3F
 CUL5 antibody  >2 publications with APOBEC3C and CUL5
 APOB antibody  >1 publications with APOBEC3C and APOB
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with APOBEC3C and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with APOBEC3C and Liver Neoplasms
 Sarcoma Antibodies  >1 publications with APOBEC3C and Sarcoma
 Carcinoma Antibodies  >1 publications with APOBEC3C and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with APOBEC3C and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >1 publications with APOBEC3C and Adenocarcinoma
Organs/Tissues associated with anti-APOBEC3C antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with APOBEC3C and Blood
 Liver Antibodies  >3 publications with APOBEC3C and Liver
 Kidney Antibodies  >2 publications with APOBEC3C and Kidney
 Brain Antibodies  >1 publications with APOBEC3C and Brain
 Prostate Antibodies  >1 publications with APOBEC3C and Prostate
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