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anti-APOC1 antibody :: Goat APOC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420037
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APOC1, Polyclonal Antibody

 Also Known As   

Goat anti-APOC1 Antibody

 Product Synonym Names    APOC1; apolipoprotein C-I; APOC1 antibody; apolipoprotein C-I antibody
 Product Gene Name   

anti-APOC1 antibody

[Similar Products]
 Antibody/Peptide Pairs    APOC1 peptide (MBS427006) is used for blocking the activity of APOC1 antibody (MBS420037)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ETFQKVKEKL KIDS
 OMIM    107710
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-ETFQKVKEKLKIDS, from the C Terminus of the protein sequence according to NP_001636.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-APOC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-APOC1 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-APOC1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Immunohistochemistry: In paraffin embedded Human Liver shows spotty staining in the cytoplasm of hepatocytes. Recommended concentration, 3-5ug/ml.
Western Blot: Preliminary experiments gave bands at 30kDa and 37kDa band in Human Liver lysates after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 9.3kDa according to NP_001636.1. The detected bands were successfully blocked by incubation with the immunizing peptide.
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 Immunohistochemistry (IHC) of anti-APOC1 antibody    (3.8ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-APOC1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for APOC1. It may not necessarily be applicable to this product.
 NCBI GI #    4502157
 NCBI GeneID    341
 NCBI Accession #    NP_001636.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001645.4 [Other Products]
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 UniProt Secondary Accession #    Q6IB97; B2R526 [Other Products]
 UniProt Related Accession #    P02654 [Other Products]
 Molecular Weight    9,332 Da
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 NCBI Official Full Name    apolipoprotein C-I
 NCBI Official Synonym Full Names    apolipoprotein C1
 NCBI Official Symbol    APOC1 [Similar Products]
 NCBI Official Synonym Symbols   
Apo-CI; ApoC-I; apo-CIB; apoC-IB
[Similar Products]
 NCBI Protein Information    apolipoprotein C-I
 UniProt Protein Name    Apolipoprotein C-I
 UniProt Synonym Protein Names   
Apolipoprotein C1
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOC1 [Similar Products]
 UniProt Synonym Gene Names    Apo-CI; ApoC-I [Similar Products]
 UniProt Entry Name    APOC1_HUMAN
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 NCBI Summary for APOC1    This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. [provided by RefSeq, Mar 2016]
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 UniProt Comments for APOC1    APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family.

Protein type: Lipid-binding; Inhibitor; Endoplasmic reticulum; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: chylomicron; endoplasmic reticulum

Molecular Function: fatty acid binding; lipase inhibitor activity; phosphatidylcholine binding; phospholipase inhibitor activity

Biological Process: cholesterol efflux; cholesterol metabolic process; lipid metabolic process; lipoprotein metabolic process; negative regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; phospholipid efflux; positive regulation of catalytic activity; regulation of cholesterol transport; triacylglycerol metabolic process
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 Research Articles on APOC1    1. The ability of apoC1 to inhibit CETP activity is impaired in patients with diabetes. Glycation of apoC1 leads to a change in its electrostatic properties that might account, at least in part, for a loss of constitutive CETP inhibition and an increase in plasma CETP activity in patients with diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOC1 antibodyPathways associated with anti-APOC1 antibody
 Reference Product  PubMed Publications
 APOE antibody  >96 publications with APOC1 and APOE
 APOC2 antibody  >31 publications with APOC1 and APOC2
 APOB antibody  >17 publications with APOC1 and APOB
 APOA1 antibody  >13 publications with APOC1 and APOA1
 APOC3 antibody  >10 publications with APOC1 and APOC3
 LPL antibody  >9 publications with APOC1 and LPL
 APOC4 antibody  >6 publications with APOC1 and APOC4
 APOA2 antibody  >6 publications with APOC1 and APOA2
 PEPD antibody  >2 publications with APOC1 and PEPD
 Products by Pathway  Pathway Diagram
 Statin Pathway antibodies  Statin Pathway Diagram
Diseases associated with anti-APOC1 antibodyOrgans/Tissues associated with anti-APOC1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >29 publications with APOC1 and Cardiovascular Diseases
 Dyslipidemias Antibodies  >24 publications with APOC1 and Dyslipidemias
 Inflammation Antibodies  >15 publications with APOC1 and Inflammation
 Atherosclerosis Antibodies  >14 publications with APOC1 and Atherosclerosis
 Heart Diseases Antibodies  >9 publications with APOC1 and Heart Diseases
 Liver Diseases Antibodies  >9 publications with APOC1 and Liver Diseases
 Memory Disorders Antibodies  >6 publications with APOC1 and Memory Disorders
 Hypertension Antibodies  >6 publications with APOC1 and Hypertension
 Fatty Liver Antibodies  >5 publications with APOC1 and Fatty Liver
 Carcinoma Antibodies  >4 publications with APOC1 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >28 publications with APOC1 and Liver
 Brain Antibodies  >16 publications with APOC1 and Brain
 Heart Antibodies  >12 publications with APOC1 and Heart
 Vascular Antibodies  >8 publications with APOC1 and Vascular
 Kidney Antibodies  >4 publications with APOC1 and Kidney
 Ovary Antibodies  >3 publications with APOC1 and Ovary
 Lung Antibodies  >3 publications with APOC1 and Lung
 Stomach Antibodies  >3 publications with APOC1 and Stomach
 Intestine Antibodies  >3 publications with APOC1 and Intestine
 Muscle Antibodies  >2 publications with APOC1 and Muscle
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