NP_000477.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
aquaporin-2
NCBI Official Synonym Full Names
aquaporin 2
NCBI Protein Information
aquaporin-2
UniProt Protein Name
Aquaporin-2
UniProt Synonym Protein Names
ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
UniProt Synonym Gene Names
UniProt Entry Name
AQP2_HUMAN
NCBI Summary for AQP2
This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
UniProt Comments for AQP2
AQP2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein type: Membrane protein, integral; Transporter; Transporter, aquaporin family; Membrane protein, multi-pass; Channel, misc.
Chromosomal Location of Human Ortholog: 12q12-q13
Cellular Component: apical plasma membrane; basolateral plasma membrane; Golgi apparatus; integral to membrane; membrane; plasma membrane; recycling endosome
Molecular Function: glycerol channel activity; glycerol transmembrane transporter activity; water channel activity; water transporter activity
Biological Process: cellular response to water deprivation; excretion; glycerol transport; renal water homeostasis; renal water transport; transmembrane transport; water transport
Disease: Diabetes Insipidus, Nephrogenic, Autosomal
Research Articles on AQP2
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Products associated with anti-AQP2 antibody
Pathways associated with anti-AQP2 antibody
Diseases associated with anti-AQP2 antibody
Organs/Tissues associated with anti-AQP2 antibody
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