NP_001305073.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,987 Da
NCBI Official Full Name
aquaporin-3 isoform 2
NCBI Official Synonym Full Names
aquaporin 3 (Gill blood group)
NCBI Official Synonym Symbols
NCBI Protein Information
aquaporin-3
UniProt Protein Name
Aquaporin-3
UniProt Synonym Protein Names
Aquaglyceroporin-3
UniProt Synonym Gene Names
UniProt Entry Name
AQP3_HUMAN
NCBI Summary for AQP3
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
UniProt Comments for AQP3
AQP3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: cytoplasm; integral to membrane; integral to plasma membrane; intercellular junction; nucleus; plasma membrane
Molecular Function: glycerol channel activity; urea transmembrane transporter activity; water channel activity
Biological Process: cellular water homeostasis; excretion; odontogenesis; positive regulation of immune system process; regulation of keratinocyte differentiation; renal water homeostasis; response to calcium ion; response to retinoic acid; response to vitamin D; water transport
Disease: Gil Blood Group
Research Articles on AQP3
Precautions
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Products associated with anti-AQP3 antibody
Pathways associated with anti-AQP3 antibody
Diseases associated with anti-AQP3 antibody
Organs/Tissues associated with anti-AQP3 antibody
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