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anti-Avpr2 antibody :: Rabbit ARG VASOPRESSIN RECEPTOR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221213 anti-Avpr2 antibody
Unit / Price
0.05 mg  /  $1,180 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARG VASOPRESSIN RECEPTOR (Avpr2), Polyclonal Antibody

 Also Known As   


 Product Gene Name   

anti-Avpr2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q00788
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Bovine (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence), Pig (Expected from Sequence)
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 Specificity    This product is specific for Arginine Vasopressin Receptor (AVPR-V2). The immunising peptide has no significant similarity with AVP V1a or V1b receptors.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
 Immunogen    21 amino acid peptide from the 3rd cytoplasmic domain of rat AVP-V2.
Buffer Solution
 Target Species    Rat
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-Avpr2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Avpr2 antibody

   This product is specific for Arginine Vasopressin Receptor (AVPR-V2). The immunising peptide has no significant similarity with AVP V1a or V1b receptors.
 Applications Tested/Suitable for anti-Avpr2 antibody   

Immunohistology Frozen, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-Avpr2 antibody    Western Blot: A glycosylated band at approximately 62 kD is observed using membranes from rat inner medulla. N-Glycanase reduces the size of this band to 36 kD (deglycosylated form).
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NCBI/Uniprot data below describe general gene information for Avpr2. It may not necessarily be applicable to this product.
 NCBI GI #    9506415
 NCBI GeneID    25108
 NCBI Accession #    NP_062009.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019136.1 [Other Products]
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 UniProt Primary Accession #    Q00788 [Other Products]
 UniProt Secondary Accession #    Q53ZC4 [Other Products]
 UniProt Related Accession #    Q00788 [Other Products]
 Molecular Weight    40,749 Da [Similar Products]
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 NCBI Official Full Name    vasopressin V2 receptor
 NCBI Official Synonym Full Names    arginine vasopressin receptor 2
 NCBI Official Symbol    Avpr2 [Similar Products]
 NCBI Protein Information    vasopressin V2 receptor; AVPR V2; V2R; Vasopressin receptor V2; antidiuretic hormone receptor; renal-type arginine vasopressin receptor
 UniProt Protein Name    Vasopressin V2 receptor
 UniProt Synonym Protein Names   
AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
 Protein Family    Vasopressin V2 receptor
 UniProt Gene Name    Avpr2 [Similar Products]
 UniProt Synonym Gene Names    V2R [Similar Products]
 UniProt Entry Name    V2R_RAT
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 NCBI Summary for Avpr2    G-protein coupled receptor for arginine vasopressin; responsible for mediation of antidiuretic effect and changes in blood pressure [RGD, Feb 2006]
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 UniProt Comments for Avpr2    AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Transporter; Transporter, aquaporin family

Cellular Component: integral to plasma membrane; integral to membrane; intracellular

Molecular Function: peptide hormone binding; vasopressin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; I-kappaB kinase/NF-kappaB cascade; telencephalon development; regulation of systemic arterial blood pressure by vasopressin; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of vasoconstriction; interferon-gamma production; positive regulation of systemic arterial blood pressure; positive regulation of blood pressure; cellular response to hormone stimulus
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 Research Articles on Avpr2    1. Data suggest that vasopressin receptors V1b (Avpr1b) and V2 (Avpr2) in neurons of cerebral ventricles mediate stress-induced baroreflex desensitization enabling concurrent hypertension and tachycardia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Avpr2 antibodyPathways associated with anti-Avpr2 antibody
 Reference Product  PubMed Publications
 Avp antibody  >45 publications with Avpr2 and Avp
 Aqp2 antibody  >36 publications with Avpr2 and Aqp2
 Oxt antibody  >1 publications with Avpr2 and Oxt
 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-Avpr2 antibody
 Disease Name  Pubmed Publications
 Diabetes Insipidus, Nephrogenic Antibodies  >98 publications with Avpr2 and Diabetes Insipidus, Nephrogenic
 Kidney Diseases Antibodies  >93 publications with Avpr2 and Kidney Diseases
 Polyuria Antibodies  >27 publications with Avpr2 and Polyuria
 Hyponatremia Antibodies  >16 publications with Avpr2 and Hyponatremia
 Genetic Diseases, X-Linked Antibodies  >15 publications with Avpr2 and Genetic Diseases, X-Linked
 Brain Diseases Antibodies  >13 publications with Avpr2 and Brain Diseases
 Inappropriate ADH Syndrome Antibodies  >11 publications with Avpr2 and Inappropriate ADH Syndrome
 Nephrogenic Syndrome of Inappropriate Antidiuresis Antibodies  >10 publications with Avpr2 and Nephrogenic Syndrome of Inappropriate Antidiuresis
 Hypertension Antibodies  >2 publications with Avpr2 and Hypertension
 Vomiting Antibodies  >2 publications with Avpr2 and Vomiting
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