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anti-ARG1 antibody :: Goat ARG1 / Arginase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243085
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARG1 / Arginase 1, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human ARG1 / Arginase 1

 Product Synonym Names    Anti-ARG1 / Arginase 1 Antibody (C-Terminus) IHC-plus; ARG1; Arginase; liver; Arginase 1; Liver-type arginase; Liver arginase; Arginase-1; Type I arginase; Human ARG1; Arginase 1
 Product Gene Name   

anti-ARG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 608313
 3D Structure    ModBase 3D Structure for P05089
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Bat, Bovine, Dog, Pig (at least 90% immunogen sequence identity)
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 Specificity    Human ARG1 / Liver Arginase.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide CFGLAREGNHKPID from the C-terminus of human ARG1 / Liver Arginase (NP_000036.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (93%), Gibbon (93%), Monkey (93%), Marmoset (93%), Panda (93%), Dog (93%).
 Immunogen Type    Synthetic peptide
 Immunogen    ARG1 / Arginase 1 antibody was raised against synthetic peptide CFGLAREGNHKPID from the C-terminus of human ARG1 / Liver Arginase (NP_000036.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (93%), Gibbon (93%), Monkey (93%), Marmoset (93%), Panda (93%), Dog (93%), Bat (93%), Bovine (93%), Pig (93%), Horse (86%), Rabbit (86%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-ARG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ARG1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ARG1 antibody    ELISA (1:64000), IHC-P (3.75 ug/ml), WB (0.01 - 0.03 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:64000. Western blot: Approx. 37kDa band observed in Human Liver lysates (calculated MW of 34.7kDa according to NP_000036.2). The observed molecular weight corresponds to earlier findings with differe...
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 Immunohistochemistry (IHC) of anti-ARG1 antibody    Anti-ARG1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-ARG1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ARG1 antibody    ARG1 antibody (0.01 ug/ml) staining of Human Liver lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ARG1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ARG1. It may not necessarily be applicable to this product.
 NCBI GI #    10947139
 NCBI GeneID    383
 NCBI Accession #    NP_000036.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000045.3 [Other Products]
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 UniProt Primary Accession #    P05089 [Other Products]
 UniProt Secondary Accession #    Q5JWT5; Q5JWT6; Q8TE72; Q9BS50; A6NEA0 [Other Products]
 UniProt Related Accession #    P05089 [Other Products]
 Molecular Weight    25,356 Da
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 NCBI Official Full Name    arginase-1 isoform 2
 NCBI Official Synonym Full Names    arginase 1
 NCBI Official Symbol    ARG1 [Similar Products]
 NCBI Protein Information    arginase-1; arginase, liver; type I arginase; liver-type arginase
 UniProt Protein Name    Arginase-1
 UniProt Synonym Protein Names   
Liver-type arginase; Type I arginase
 Protein Family    Arginase
 UniProt Gene Name    ARG1 [Similar Products]
 UniProt Entry Name    ARGI1_HUMAN
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 NCBI Summary for ARG1    Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for ARG1    ARG1: Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.5.3.1; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: extracellular space; neuron projection; cell soma; cytoplasm; nucleus; cytosol

Molecular Function: manganese ion binding; arginase activity

Biological Process: response to drug; mammary gland involution; maternal process involved in pregnancy; response to herbicide; liver development; response to amino acid stimulus; response to vitamin A; response to manganese ion; response to selenium ion; response to vitamin E; response to cadmium ion; response to zinc ion; response to methylmercury; arginine catabolic process; positive regulation of endothelial cell proliferation; response to axon injury; collagen biosynthetic process; lung development; urea cycle; response to amine stimulus

Disease: Argininemia
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 Research Articles on ARG1    1. Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARG1 antibodyPathways associated with anti-ARG1 antibody
 Reference Product  PubMed Publications
 NOS2 antibody  >56 publications with ARG1 and NOS2
 NOS3 antibody  >13 publications with ARG1 and NOS3
 STAT3 antibody  >8 publications with ARG1 and STAT3
 ASL antibody  >6 publications with ARG1 and ASL
 NOS1 antibody  >6 publications with ARG1 and NOS1
 OTC antibody  >5 publications with ARG1 and OTC
 OAT antibody  >2 publications with ARG1 and OAT
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with anti-ARG1 antibodyOrgans/Tissues associated with anti-ARG1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >107 publications with ARG1 and Inflammation
 Lung Diseases Antibodies  >60 publications with ARG1 and Lung Diseases
 Disease Models, Animal Antibodies  >59 publications with ARG1 and Disease Models, Animal
 Immune System Diseases Antibodies  >43 publications with ARG1 and Immune System Diseases
 Necrosis Antibodies  >34 publications with ARG1 and Necrosis
 Cardiovascular Diseases Antibodies  >30 publications with ARG1 and Cardiovascular Diseases
 Asthma Antibodies  >28 publications with ARG1 and Asthma
 Fibrosis Antibodies  >22 publications with ARG1 and Fibrosis
 Lung Neoplasms Antibodies  >21 publications with ARG1 and Lung Neoplasms
 Liver Diseases Antibodies  >20 publications with ARG1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >204 publications with ARG1 and Blood
 Muscle Antibodies  >110 publications with ARG1 and Muscle
 Lung Antibodies  >84 publications with ARG1 and Lung
 Brain Antibodies  >84 publications with ARG1 and Brain
 Liver Antibodies  >59 publications with ARG1 and Liver
 Bone Marrow Antibodies  >36 publications with ARG1 and Bone Marrow
 Eye Antibodies  >26 publications with ARG1 and Eye
 Spleen Antibodies  >25 publications with ARG1 and Spleen
 Skin Antibodies  >18 publications with ARG1 and Skin
 Uterus Antibodies  >11 publications with ARG1 and Uterus
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