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anti-ARHGAP22 antibody :: Rabbit ARHGAP22 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS821095
Immunohistochemistry (IHC)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARHGAP22, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-ARHGAP22 Antibody

 Product Synonym Names    RHOGAP2; Rho GTPase-activating protein 22; Rho-type GTPase-activating protein 22
 Product Gene Name   

anti-ARHGAP22 antibody

[Similar Products]
 Antibody/Peptide Pairs    ARHGAP22 peptide (MBS823957) is used for blocking the activity of ARHGAP22 antibody (MBS821095)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610585
 3D Structure    ModBase 3D Structure for Q7Z5H3
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of ARHGAP22 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ARHGAP22. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-ARHGAP22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ARHGAP22 antibody

   Rabbit polyclonal antibody to ARHGAP22
 Applications Tested/Suitable for anti-ARHGAP22 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ARHGAP22 antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200)
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 Western Blot (WB) of anti-ARHGAP22 antibody    anti-ARHGAP22 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ARHGAP22 antibody    Immunohistochemical analysis of ARHGAP22 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-ARHGAP22 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ARHGAP22. It may not necessarily be applicable to this product.
 NCBI GI #    365733566
 NCBI GeneID    58504
 NCBI Accession #    NP_001242953.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256024.1 [Other Products]
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 UniProt Primary Accession #    Q7Z5H3 [Other Products]
 UniProt Secondary Accession #    O00152; Q6ZSB0; A0AVP7; A5YM75; B4DED8; B9EGA0; C9JDM2 [Other Products]
 UniProt Related Accession #    Q7Z5H3 [Other Products]
 Molecular Weight    77,457 Da
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 NCBI Official Full Name    rho GTPase-activating protein 22 isoform 1
 NCBI Official Synonym Full Names    Rho GTPase activating protein 22
 NCBI Official Symbol    ARHGAP22 [Similar Products]
 NCBI Official Synonym Symbols   
RhoGAP2; RhoGap22
[Similar Products]
 NCBI Protein Information    rho GTPase-activating protein 22; rho-type GTPase-activating protein 22
 UniProt Protein Name    Rho GTPase-activating protein 22
 UniProt Synonym Protein Names   
Rho-type GTPase-activating protein 22
 Protein Family    Rho GTPase-activating protein
 UniProt Gene Name    ARHGAP22 [Similar Products]
 UniProt Synonym Gene Names    RHOGAP2 [Similar Products]
 UniProt Entry Name    RHG22_HUMAN
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 NCBI Summary for ARHGAP22    This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for ARHGAP22    ARHGAP22: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: focal adhesion; nucleus; cytosol

Molecular Function: protein binding; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; angiogenesis; cell differentiation; positive regulation of GTPase activity
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 Research Articles on ARHGAP22    1. a weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARHGAP22 antibodyPathways associated with anti-ARHGAP22 antibody
 Reference Product  PubMed Publications
 ARHGAP4 antibody  >2 publications with ARHGAP22 and ARHGAP4
 Products by Pathway  Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
Diseases associated with anti-ARHGAP22 antibodyOrgans/Tissues associated with anti-ARHGAP22 antibody
 Disease Name  Pubmed Publications
 Spinal Cord Diseases Antibodies  >1 publications with ARHGAP22 and Spinal Cord Diseases
 Nervous System Diseases Antibodies  >1 publications with ARHGAP22 and Nervous System Diseases
 Atrophy Antibodies  >1 publications with ARHGAP22 and Atrophy
 Cardiovascular Diseases Antibodies  >1 publications with ARHGAP22 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with ARHGAP22 and Eye
 Lung Antibodies  >2 publications with ARHGAP22 and Lung
 Kidney Antibodies  >1 publications with ARHGAP22 and Kidney
 Spleen Antibodies  >1 publications with ARHGAP22 and Spleen
 Brain Antibodies  >1 publications with ARHGAP22 and Brain
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