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anti-ARHGDIA antibody :: Rabbit ARHGDIA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2517804
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARHGDIA, Polyclonal Antibody

 Also Known As   

ARHGDIA Polyclonal Antibody

 Product Synonym Names    GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e
 Product Gene Name   

anti-ARHGDIA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601925
 3D Structure    ModBase 3D Structure for P52565
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2.4mg/mL (lot specific)
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 Immunogen    Recombinant protein of human ARHGDIA
 Calculated Molecular Weight: 23kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-ARHGDIA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ARHGDIA antibody

   Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA 
 Applications Tested/Suitable for anti-ARHGDIA antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ARHGDIA antibody    WB: 1:500-1:2000
IHC: 1:100-1:300
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 Immunohistochemistry (IHC) of anti-ARHGDIA antibody    Immunohistochemistry of Human breast cancer using ARHGDIA Polyclonal Antibody at dilution of 1:50
anti-ARHGDIA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ARHGDIA. It may not necessarily be applicable to this product.
 NCBI GI #    48145671
 NCBI GeneID    396
 NCBI Accession #    CAG33058.1 [Other Products]
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 UniProt Primary Accession #    P52565 [Other Products]
 UniProt Secondary Accession #    Q6IBM5; A8MXW0; B2R5X1; B4DDD3; B4DUV9 [Other Products]
 UniProt Related Accession #    P52565 [Other Products]
 Molecular Weight    18,233 Da
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 NCBI Official Full Name    ARHGDIA
 NCBI Official Synonym Full Names    Rho GDP dissociation inhibitor (GDI) alpha
 NCBI Official Symbol    ARHGDIA [Similar Products]
 NCBI Official Synonym Symbols   
GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e
[Similar Products]
 NCBI Protein Information    rho GDP-dissociation inhibitor 1; GDP-dissociation inhibitor, aplysia RAS-related 1; epididymis secretory sperm binding protein Li 47e
 UniProt Protein Name    Rho GDP-dissociation inhibitor 1
 UniProt Synonym Protein Names   
Rho-GDI alpha
 UniProt Gene Name    ARHGDIA [Similar Products]
 UniProt Synonym Gene Names    GDIA1; Rho GDI 1 [Similar Products]
 UniProt Entry Name    GDIR1_HUMAN
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 NCBI Summary for ARHGDIA    This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for ARHGDIA    RhoGDI alpha: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Monomer. Forms a heterodimer with RAC1. Interacts with FER. Belongs to the Rho GDI family.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Apoptosis; Cell adhesion; G protein regulator, misc.

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytoskeleton; immunological synapse; cytosol

Molecular Function: protein binding; Rho GDP-dissociation inhibitor activity; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; regulation of protein localization; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; negative regulation of axonogenesis; positive regulation of axonogenesis; negative regulation of cell adhesion; cell motility; regulation of axonogenesis; negative regulation of cell migration; Rho protein signal transduction; negative regulation of apoptosis; positive regulation of GTPase activity

Disease: Nephrotic Syndrome, Type 8
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 Research Articles on ARHGDIA    1. the present study has identified loss of ARHGDIA contributed to the processes of hepatic tumorigenesis, in particular invasion and metastasis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARHGDIA antibodyPathways associated with anti-ARHGDIA antibody
 Reference Product  PubMed Publications
 RHOA antibody  >44 publications with ARHGDIA and RHOA
 RAC1 antibody  >32 publications with ARHGDIA and RAC1
 CDC42 antibody  >28 publications with ARHGDIA and CDC42
 RHOB antibody  >5 publications with ARHGDIA and RHOB
 RAC2 antibody  >2 publications with ARHGDIA and RAC2
 NGFR antibody  >1 publications with ARHGDIA and NGFR
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
Diseases associated with anti-ARHGDIA antibodyOrgans/Tissues associated with anti-ARHGDIA antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >9 publications with ARHGDIA and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >7 publications with ARHGDIA and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >4 publications with ARHGDIA and Cardiovascular Diseases
 Brain Diseases Antibodies  >4 publications with ARHGDIA and Brain Diseases
 Kidney Diseases Antibodies  >4 publications with ARHGDIA and Kidney Diseases
 Nervous System Diseases Antibodies  >4 publications with ARHGDIA and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with ARHGDIA and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >4 publications with ARHGDIA and Breast Neoplasms
 Central Nervous System Diseases Antibodies  >3 publications with ARHGDIA and Central Nervous System Diseases
 Liver Diseases Antibodies  >3 publications with ARHGDIA and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ARHGDIA and Brain
 Muscle Antibodies  >7 publications with ARHGDIA and Muscle
 Blood Antibodies  >6 publications with ARHGDIA and Blood
 Lung Antibodies  >6 publications with ARHGDIA and Lung
 Kidney Antibodies  >5 publications with ARHGDIA and Kidney
 Bone Antibodies  >4 publications with ARHGDIA and Bone
 Liver Antibodies  >3 publications with ARHGDIA and Liver
 Bone Marrow Antibodies  >3 publications with ARHGDIA and Bone Marrow
 Vascular Antibodies  >3 publications with ARHGDIA and Vascular
 Heart Antibodies  >3 publications with ARHGDIA and Heart
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