NP_001166.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,988 Da
NCBI Official Full Name
rho GDP-dissociation inhibitor 2
NCBI Official Synonym Full Names
Rho GDP dissociation inhibitor (GDI) beta
NCBI Official Synonym Symbols
D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2 [Similar Products]
NCBI Protein Information
rho GDP-dissociation inhibitor 2; Rho GDI 2; rho-GDI beta
UniProt Protein Name
Rho GDP-dissociation inhibitor 2
UniProt Synonym Protein Names
Ly-GDI; Rho-GDI beta
UniProt Synonym Gene Names
UniProt Entry Name
GDIR2_HUMAN
NCBI Summary for ARHGDIB
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
UniProt Comments for ARHGDIB
RhoGDI beta: regulates the GDP/GTP exchange reaction of Rho proteins by inhibiting the dissociation of GDP from them, keeping these small GTPases in an inactive state. The GDIs are made up of two domains: a flexible N-terminal domain of about 70 amino acid residues and a folded 134-residue C-terminal domain. Regulates the GTP/GDP cycling of glucose-responsive small GTPases. Its phosphorylation on Y156, S101, and S174 mediates the cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion. Interacts with WNK1.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; G protein regulator, misc.
Chromosomal Location of Human Ortholog: 12p12.3
Cellular Component: cytoskeleton; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol
Molecular Function: Rho GDP-dissociation inhibitor activity; GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction; regulation of catalytic activity; small GTPase mediated signal transduction; multicellular organismal development; immune response; negative regulation of cell adhesion; actin cytoskeleton organization and biogenesis; cell motility; Rho protein signal transduction; positive regulation of GTPase activity
Research Articles on ARHGDIB
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Products associated with anti-ARHGDIB antibody
Pathways associated with anti-ARHGDIB antibody
Diseases associated with anti-ARHGDIB antibody
Organs/Tissues associated with anti-ARHGDIB antibody
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