NP_004697.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
rho guanine nucleotide exchange factor 1 isoform 2
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor (GEF) 1
NCBI Official Synonym Symbols
LSC; GEF1; LBCL2; SUB1.5; P115-RHOGEF [Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 1
UniProt Protein Name
Rho guanine nucleotide exchange factor 1
UniProt Synonym Protein Names
115 kDa guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; Sub1.5
UniProt Synonym Gene Names
UniProt Entry Name
ARHG1_HUMAN
NCBI Summary for ARHGEF1
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
UniProt Comments for ARHGEF1
ARHGEF1: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1. Interacts with CTNNAL1. Ubiquitously expressed. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; GEFs; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; GTPase activator activity
Biological Process: cell proliferation; nerve growth factor receptor signaling pathway; negative regulation of axonogenesis; regulation of axonogenesis; Rho protein signal transduction
Product References and Citations for anti-ARHGEF1 antibody
Hart M.J.,et al.J. Biol. Chem. 271:25452-25458(1996). Aasheim H.-C.,et al.Oncogene 14:1747-1752(1997). Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. Kozasa T.,et al.Science 280:2109-2111(1998). Hart M.J.,et al.Science 280:2112-2114(1998).
Research Articles on ARHGEF1
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Products associated with anti-ARHGEF1 antibody
Pathways associated with anti-ARHGEF1 antibody
Diseases associated with anti-ARHGEF1 antibody
Organs/Tissues associated with anti-ARHGEF1 antibody
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